Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50574191 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2121954 (CHEMBL4831101) |
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Ki | 1.6±n/a nM |
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Citation | Wichur, T; Gody?, J; Góral, I; Latacz, G; Bucki, A; Siwek, A; G?uch-Lutwin, M; Mordyl, B; ?niecikowska, J; Walczak, M; Knez, D; Juki?, M; Sa?at, K; Gobec, S; Ko?aczkowski, M; Malawska, B; Brazzolotto, X; Wi?ckowska, A Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT Eur J Med Chem225:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50574191 |
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n/a |
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Name | BDBM50574191 |
Synonyms: | CHEMBL178254 |
Type | Small organic molecule |
Emp. Form. | C17H18N2O3S |
Mol. Mass. | 330.401 |
SMILES | CNCCOc1cccc2n(ccc12)S(=O)(=O)c1ccccc1 |
Structure |
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