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TargetLysine-specific demethylase 4D
LigandBDBM50574748
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2123087 (CHEMBL4832320)
IC50 45±n/a nM
Citation Fang, ZLiu, YZhang, RChen, QWang, TYang, WFan, YYu, CXiang, RYang, S Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D. Eur J Med Chem223:0 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysine-specific demethylase 4D
Name:Lysine-specific demethylase 4D
Synonyms:JHDM3D | JHDM3D | JMJD2D | JmjC domain-containing histone demethylation protein 3D | Jumonji domain-containing protein 2D | KDM4D | KDM4D_HUMAN | Lysine-specific demethylase 4D
Type:PROTEIN
Mol. Mass.:58627.79
Organism:Homo sapiens (Human)
Description:ChEMBL_102441
Residue:523
Sequence:
METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR
ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED
LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL
YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA
FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW
IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST
QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRA
AAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTT
CTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
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  Blast E-value cutoff:
BDBM50574748
n/a
NameBDBM50574748
Synonyms:CHEMBL4875100
TypeSmall organic molecule
Emp. Form.C23H26N4O5
Mol. Mass.438.4763
SMILESCC(C)(C)OC(=O)N[C@@H]1CCN(C1)C(c1ccc(cn1)C#N)c1cc2OCOc2cc1O |r|
Structure
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