| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
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| Ligand | BDBM50141726 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_105136 |
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| IC50 | 68000±n/a nM |
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| Citation |  Sheppard, GS; Wang, J; Kawai, M; BaMaung, NY; Craig, RA; Erickson, SA; Lynch, L; Patel, J; Yang, F; Searle, XB; Lou, P; Park, C; Kim, KH; Henkin, J; Lesniewski, R 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2. Bioorg Med Chem Lett14:865-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 1 |
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| Name: | Methionine aminopeptidase 1 |
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| Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43220.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
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| Residue: | 386 |
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| Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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| BDBM50141726 |
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| n/a |
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| Name | BDBM50141726 |
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| Synonyms: | 3-Amino-4-cyclohexyl-2-(S)-hydroxy-N-((R)-2-hydroxy-1-phenyl-ethyl)-butyramide | CHEMBL169423 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H28N2O3 |
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| Mol. Mass. | 320.4265 |
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| SMILES | N[C@H](CC1CCCCC1)[C@H](O)C(=O)N[C@@H](CO)c1ccccc1 |
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| Structure | 
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