Compile Data Set for Download or QSAR

Found 457 hits with Last Name = 'erickson' and Initial = 'sa'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human))	BDBM27970 (1-{4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohex...) Show SMILES COc1ccccc1Cc1nc2ccc(cc2[nH]1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(CC3CC3)CC2)c2ncnc(N)c12 |r,wU:24.30,wD:21.23,(8.83,13.92,;7.49,13.15,;7.49,11.61,;8.83,10.84,;8.83,9.3,;7.49,8.53,;6.16,9.3,;6.16,10.84,;4.72,11.39,;3.53,10.41,;2.04,10.8,;1.21,9.5,;-.31,9.25,;-.85,7.81,;.12,6.62,;1.64,6.87,;2.19,8.31,;3.62,8.87,;-.35,5.15,;.55,3.91,;-.35,2.66,;.42,1.33,;-.41,.03,;.29,-1.34,;1.83,-1.41,;2.66,-.11,;1.96,1.26,;2.6,-2.74,;1.94,-4.13,;2.81,-5.4,;4.35,-5.28,;5.22,-6.55,;6.75,-6.43,;8.01,-5.54,;8.15,-7.08,;5.01,-3.89,;4.14,-2.62,;-1.82,3.14,;-3.15,2.37,;-4.48,3.14,;-4.48,4.68,;-3.15,5.45,;-3.15,6.99,;-1.82,4.68,)| Show InChI InChI=1S/C34H41N9O/c1-44-29-5-3-2-4-23(29)19-30-38-27-13-8-24(18-28(27)39-30)32-31-33(35)36-21-37-34(31)43(40-32)26-11-9-25(10-12-26)42-16-14-41(15-17-42)20-22-6-7-22/h2-5,8,13,18,21-22,25-26H,6-7,9-12,14-17,19-20H2,1H3,(H,38,39)(H2,35,36,37)/t25-,26-	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	23
Abbott Laboratories					Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...				Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50315895 (CHEMBL1090357 | N-(3-(5-(2-(4-(2-(dimethylamino)et...) Show SMILES CN(C)CCc1ccc(Nc2nccc(n2)-c2c(nc3sccn23)-c2cccc(NC(=O)c3c(F)cccc3F)c2)cc1 Show InChI InChI=1S/C32H27F2N7OS/c1-40(2)16-14-20-9-11-22(12-10-20)37-31-35-15-13-26(38-31)29-28(39-32-41(29)17-18-43-32)21-5-3-6-23(19-21)36-30(42)27-24(33)7-4-8-25(27)34/h3-13,15,17-19H,14,16H2,1-2H3,(H,36,42)(H,35,37,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of ErbB2 by time resolved fluorescence assay				Bioorg Med Chem Lett 20: 2452-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.015 BindingDB Entry DOI: 10.7270/Q2M908VT
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50315905 (CHEMBL1090350 | N-(3-(5-(2-(4-morpholinophenylamin...) Show SMILES O=C(Nc1cccc(c1)-c1nc2sccn2c1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1)c1ccccc1 Show InChI InChI=1S/C32H27N7O2S/c40-30(22-5-2-1-3-6-22)34-25-8-4-7-23(21-25)28-29(39-17-20-42-32(39)37-28)27-13-14-33-31(36-27)35-24-9-11-26(12-10-24)38-15-18-41-19-16-38/h1-14,17,20-21H,15-16,18-19H2,(H,34,40)(H,33,35,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of ErbB2 by time resolved fluorescence assay				Bioorg Med Chem Lett 20: 2452-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.015 BindingDB Entry DOI: 10.7270/Q2M908VT
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50315903 (CHEMBL1093234 | N-(3-(5-(2-(phenylamino)pyrimidin-...) Show SMILES O=C(Nc1cccc(c1)-c1nc2sccn2c1-c1ccnc(Nc2ccccc2)n1)c1ccccc1 Show InChI InChI=1S/C28H20N6OS/c35-26(19-8-3-1-4-9-19)30-22-13-7-10-20(18-22)24-25(34-16-17-36-28(34)33-24)23-14-15-29-27(32-23)31-21-11-5-2-6-12-21/h1-18H,(H,30,35)(H,29,31,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of ErbB2 by time resolved fluorescence assay				Bioorg Med Chem Lett 20: 2452-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.015 BindingDB Entry DOI: 10.7270/Q2M908VT
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50315897 (2,6-difluoro-N-(3-(5-(2-(1,2,3,4-tetrahydroisoquin...) Show SMILES Fc1cccc(F)c1C(=O)Nc1cccc(c1)-c1nc2sccn2c1-c1ccnc(Nc2ccc3CNCCc3c2)n1 Show InChI InChI=1S/C31H23F2N7OS/c32-23-5-2-6-24(33)26(23)29(41)36-21-4-1-3-19(16-21)27-28(40-13-14-42-31(40)39-27)25-10-12-35-30(38-25)37-22-8-7-20-17-34-11-9-18(20)15-22/h1-8,10,12-16,34H,9,11,17H2,(H,36,41)(H,35,37,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of ErbB2 by time resolved fluorescence assay				Bioorg Med Chem Lett 20: 2452-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.015 BindingDB Entry DOI: 10.7270/Q2M908VT
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17573 (2-({2-[(1Z)-3-[ethyl(methyl)amino]prop-1-en-1-yl]b...) Show SMILES CCN(C)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C23H28N2O4S/c1-3-25(2)16-8-11-18-10-5-7-13-21(18)30(28,29)24-20-15-14-17-9-4-6-12-19(17)22(20)23(26)27/h5,7-8,10-11,13-15,24H,3-4,6,9,12,16H2,1-2H3,(H,26,27)/b11-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17478 (2-benzenesulfonamido-5,6,7,8-tetrahydronaphthalene...) Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2)ccc2CCCCc12 Show InChI InChI=1S/C17H17NO4S/c19-17(20)16-14-9-5-4-6-12(14)10-11-15(16)18-23(21,22)13-7-2-1-3-8-13/h1-3,7-8,10-11,18H,4-6,9H2,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				Bioorg Med Chem Lett 16: 3574-7 (2006) Article DOI: 10.1016/j.bmcl.2006.03.085 BindingDB Entry DOI: 10.7270/Q2TB1556
					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17579 (2-({2-[3-(diethylamino)propyl]benzene}sulfonamido)...) Show SMILES CCN(CC)CCCc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H32N2O4S/c1-3-26(4-2)17-9-12-19-11-6-8-14-22(19)31(29,30)25-21-16-15-18-10-5-7-13-20(18)23(21)24(27)28/h6,8,11,14-16,25H,3-5,7,9-10,12-13,17H2,1-2H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17564 (2-({4-fluoro-2-[(1Z)-3-(pyrrolidin-1-yl)but-1-en-1...) Show SMILES CC(\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O)N1CCCC1 Show InChI InChI=1S/C25H29FN2O4S/c1-17(28-14-4-5-15-28)8-9-19-16-20(26)11-13-23(19)33(31,32)27-22-12-10-18-6-2-3-7-21(18)24(22)25(29)30/h8-13,16-17,27H,2-7,14-15H2,1H3,(H,29,30)/b9-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17583 (2-({2-[3-(dimethylamino)propyl]benzene}sulfonamido...) Show SMILES CN(C)CCCc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C22H28N2O4S/c1-24(2)15-7-10-17-9-4-6-12-20(17)29(27,28)23-19-14-13-16-8-3-5-11-18(16)21(19)22(25)26/h4,6,9,12-14,23H,3,5,7-8,10-11,15H2,1-2H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17505 (2-[(2-{[3-(1H-imidazol-1-yl)propyl]amino}benzene)s...) Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCCn2ccnc2)ccc2CCCCc12 Show InChI InChI=1S/C23H26N4O4S/c28-23(29)22-18-7-2-1-6-17(18)10-11-20(22)26-32(30,31)21-9-4-3-8-19(21)25-12-5-14-27-15-13-24-16-27/h3-4,8-11,13,15-16,25-26H,1-2,5-7,12,14H2,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17478 (2-benzenesulfonamido-5,6,7,8-tetrahydronaphthalene...) Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2)ccc2CCCCc12 Show InChI InChI=1S/C17H17NO4S/c19-17(20)16-14-9-5-4-6-12(14)10-11-15(16)18-23(21,22)13-7-2-1-3-8-13/h1-3,7-8,10-11,18H,4-6,9H2,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17607 (2-[(4-fluorobenzene)sulfonamido]-5,6,7,8-tetrahydr...) Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2)ccc2CCCCc12 Show InChI InChI=1S/C17H16FNO4S/c18-12-6-8-13(9-7-12)24(22,23)19-15-10-5-11-3-1-2-4-14(11)16(15)17(20)21/h5-10,19H,1-4H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				Bioorg Med Chem Lett 16: 3574-7 (2006) Article DOI: 10.1016/j.bmcl.2006.03.085 BindingDB Entry DOI: 10.7270/Q2TB1556
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17560 (2-({2-[(1Z)-3-(diethylamino)prop-1-en-1-yl]-4-fluo...) Show SMILES CCN(CC)C\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H29FN2O4S/c1-3-27(4-2)15-7-9-18-16-19(25)12-14-22(18)32(30,31)26-21-13-11-17-8-5-6-10-20(17)23(21)24(28)29/h7,9,11-14,16,26H,3-6,8,10,15H2,1-2H3,(H,28,29)/b9-7-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17559 (2-({2-[(1Z)-3-(diethylamino)prop-1-en-1-yl]benzene...) Show SMILES CCN(CC)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H30N2O4S/c1-3-26(4-2)17-9-12-19-11-6-8-14-22(19)31(29,30)25-21-16-15-18-10-5-7-13-20(18)23(21)24(27)28/h6,8-9,11-12,14-16,25H,3-5,7,10,13,17H2,1-2H3,(H,27,28)/b12-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17519 (2-[(2-{[4-(dimethylamino)butyl]amino}benzene)sulfo...) Show SMILES CN(C)CCCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C23H31N3O4S/c1-26(2)16-8-7-15-24-19-11-5-6-12-21(19)31(29,30)25-20-14-13-17-9-3-4-10-18(17)22(20)23(27)28/h5-6,11-14,24-25H,3-4,7-10,15-16H2,1-2H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17488 (2-[(2-{[3-(ethylamino)propyl]amino}benzene)sulfona...) Show SMILES CCNCCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C22H29N3O4S/c1-2-23-14-7-15-24-18-10-5-6-11-20(18)30(28,29)25-19-13-12-16-8-3-4-9-17(16)21(19)22(26)27/h5-6,10-13,23-25H,2-4,7-9,14-15H2,1H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17575 (2-({2-[(1Z)-3-[methyl(propan-2-yl)amino]prop-1-en-...) Show SMILES CC(C)N(C)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H30N2O4S/c1-17(2)26(3)16-8-11-19-10-5-7-13-22(19)31(29,30)25-21-15-14-18-9-4-6-12-20(18)23(21)24(27)28/h5,7-8,10-11,13-15,17,25H,4,6,9,12,16H2,1-3H3,(H,27,28)/b11-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM27970 (1-{4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohex...) Show SMILES COc1ccccc1Cc1nc2ccc(cc2[nH]1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(CC3CC3)CC2)c2ncnc(N)c12 |r,wU:24.30,wD:21.23,(8.83,13.92,;7.49,13.15,;7.49,11.61,;8.83,10.84,;8.83,9.3,;7.49,8.53,;6.16,9.3,;6.16,10.84,;4.72,11.39,;3.53,10.41,;2.04,10.8,;1.21,9.5,;-.31,9.25,;-.85,7.81,;.12,6.62,;1.64,6.87,;2.19,8.31,;3.62,8.87,;-.35,5.15,;.55,3.91,;-.35,2.66,;.42,1.33,;-.41,.03,;.29,-1.34,;1.83,-1.41,;2.66,-.11,;1.96,1.26,;2.6,-2.74,;1.94,-4.13,;2.81,-5.4,;4.35,-5.28,;5.22,-6.55,;6.75,-6.43,;8.01,-5.54,;8.15,-7.08,;5.01,-3.89,;4.14,-2.62,;-1.82,3.14,;-3.15,2.37,;-4.48,3.14,;-4.48,4.68,;-3.15,5.45,;-3.15,6.99,;-1.82,4.68,)| Show InChI InChI=1S/C34H41N9O/c1-44-29-5-3-2-4-23(29)19-30-38-27-13-8-24(18-28(27)39-30)32-31-33(35)36-21-37-34(31)43(40-32)26-11-9-25(10-12-26)42-16-14-41(15-17-42)20-22-6-7-22/h2-5,8,13,18,21-22,25-26H,6-7,9-12,14-17,19-20H2,1H3,(H,38,39)(H2,35,36,37)/t25-,26-	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	23
Abbott Laboratories					Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...				Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17521 (2-[(2-aminobenzene)sulfonamido]-5,6,7,8-tetrahydro...) Show SMILES Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C17H18N2O4S/c18-13-7-3-4-8-15(13)24(22,23)19-14-10-9-11-5-1-2-6-12(11)16(14)17(20)21/h3-4,7-10,19H,1-2,5-6,18H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17492 (2-({2-[(3-aminopropyl)amino]benzene}sulfonamido)-5...) Show SMILES NCCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C20H25N3O4S/c21-12-5-13-22-16-8-3-4-9-18(16)28(26,27)23-17-11-10-14-6-1-2-7-15(14)19(17)20(24)25/h3-4,8-11,22-23H,1-2,5-7,12-13,21H2,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17483 (2-[(2-{[3-(dimethylamino)propyl]amino}benzene)sulf...) Show SMILES CN(C)CCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C22H29N3O4S/c1-25(2)15-7-14-23-18-10-5-6-11-20(18)30(28,29)24-19-13-12-16-8-3-4-9-17(16)21(19)22(26)27/h5-6,10-13,23-24H,3-4,7-9,14-15H2,1-2H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50315896 (CHEMBL1090358 | N-(3-(5-(2-(4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2c(nc3sccn23)-c2cccc(NC(=O)c3c(F)cccc3F)c2)cc1 Show InChI InChI=1S/C34H30F2N8OS/c1-2-42-15-17-43(18-16-42)25-11-9-23(10-12-25)39-33-37-14-13-28(40-33)31-30(41-34-44(31)19-20-46-34)22-5-3-6-24(21-22)38-32(45)29-26(35)7-4-8-27(29)36/h3-14,19-21H,2,15-18H2,1H3,(H,38,45)(H,37,39,40)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of ErbB2 by time resolved fluorescence assay				Bioorg Med Chem Lett 20: 2452-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.015 BindingDB Entry DOI: 10.7270/Q2M908VT
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17569 (2-({2-[(1Z)-3-[ethyl(2-hydroxyethyl)amino]prop-1-e...) Show SMILES CCN(CCO)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H30N2O5S/c1-2-26(16-17-27)15-7-10-19-9-4-6-12-22(19)32(30,31)25-21-14-13-18-8-3-5-11-20(18)23(21)24(28)29/h4,6-7,9-10,12-14,25,27H,2-3,5,8,11,15-17H2,1H3,(H,28,29)/b10-7-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17574 (2-({2-[(1Z)-3-[(2-hydroxyethyl)(methyl)amino]prop-...) Show SMILES CN(CCO)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C23H28N2O5S/c1-25(15-16-26)14-6-9-18-8-3-5-11-21(18)31(29,30)24-20-13-12-17-7-2-4-10-19(17)22(20)23(27)28/h3,5-6,8-9,11-13,24,26H,2,4,7,10,14-16H2,1H3,(H,27,28)/b9-6-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17527 (2-[(2-{[(1-methylpiperidin-4-yl)methyl]amino}benze...) Show SMILES CN1CCC(CNc2ccccc2S(=O)(=O)Nc2ccc3CCCCc3c2C(O)=O)CC1 Show InChI InChI=1S/C24H31N3O4S/c1-27-14-12-17(13-15-27)16-25-20-8-4-5-9-22(20)32(30,31)26-21-11-10-18-6-2-3-7-19(18)23(21)24(28)29/h4-5,8-11,17,25-26H,2-3,6-7,12-16H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17489 (2-{[2-({3-[(2-hydroxyethyl)amino]propyl}amino)benz...) Show SMILES OCCNCCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C22H29N3O5S/c26-15-14-23-12-5-13-24-18-8-3-4-9-20(18)31(29,30)25-19-11-10-16-6-1-2-7-17(16)21(19)22(27)28/h3-4,8-11,23-26H,1-2,5-7,12-15H2,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17512 (2-[(3-chloro-2-{[3-(diethylamino)propyl]amino}benz...) Show SMILES CCN(CC)CCCNc1c(Cl)cccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H32ClN3O4S/c1-3-28(4-2)16-8-15-26-23-19(25)11-7-12-21(23)33(31,32)27-20-14-13-17-9-5-6-10-18(17)22(20)24(29)30/h7,11-14,26-27H,3-6,8-10,15-16H2,1-2H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17604 (2-[(4-fluorobenzene)sulfonamido]naphthalene-1-carb...) Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2)ccc2ccccc12 Show InChI InChI=1S/C17H12FNO4S/c18-12-6-8-13(9-7-12)24(22,23)19-15-10-5-11-3-1-2-4-14(11)16(15)17(20)21/h1-10,19H,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				Bioorg Med Chem Lett 16: 3574-7 (2006) Article DOI: 10.1016/j.bmcl.2006.03.085 BindingDB Entry DOI: 10.7270/Q2TB1556
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17561 (2-({2-[(1Z)-4-(diethylamino)but-1-en-1-yl]benzene}...) Show SMILES CCN(CC)CC\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C25H32N2O4S/c1-3-27(4-2)18-10-9-13-20-12-6-8-15-23(20)32(30,31)26-22-17-16-19-11-5-7-14-21(19)24(22)25(28)29/h6,8-9,12-13,15-17,26H,3-5,7,10-11,14,18H2,1-2H3,(H,28,29)/b13-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17508 (2-[(2-{[2-(pyridin-4-yl)ethyl]amino}benzene)sulfon...) Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCc2ccncc2)ccc2CCCCc12 Show InChI InChI=1S/C24H25N3O4S/c28-24(29)23-19-6-2-1-5-18(19)9-10-21(23)27-32(30,31)22-8-4-3-7-20(22)26-16-13-17-11-14-25-15-12-17/h3-4,7-12,14-15,26-27H,1-2,5-6,13,16H2,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17566 (2-({2-[(1Z)-3-(diethylamino)but-1-en-1-yl]-4-fluor...) Show SMILES CCN(CC)C(C)\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C25H31FN2O4S/c1-4-28(5-2)17(3)10-11-19-16-20(26)13-15-23(19)33(31,32)27-22-14-12-18-8-6-7-9-21(18)24(22)25(29)30/h10-17,27H,4-9H2,1-3H3,(H,29,30)/b11-10-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17571 (2-({2-[(1Z)-3-(dimethylamino)prop-1-en-1-yl]benzen...) Show SMILES CN(C)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C22H26N2O4S/c1-24(2)15-7-10-17-9-4-6-12-20(17)29(27,28)23-19-14-13-16-8-3-5-11-18(16)21(19)22(25)26/h4,6-7,9-10,12-14,23H,3,5,8,11,15H2,1-2H3,(H,25,26)/b10-7-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17580 (2-({2-[3-(diethylamino)propyl]-4-fluorobenzene}sul...) Show SMILES CCN(CC)CCCc1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H31FN2O4S/c1-3-27(4-2)15-7-9-18-16-19(25)12-14-22(18)32(30,31)26-21-13-11-17-8-5-6-10-20(17)23(21)24(28)29/h11-14,16,26H,3-10,15H2,1-2H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM27968 (4-[4-(4-amino-3-{2-[(2-methoxyphenyl)methyl]-1H-1,...) Show SMILES COc1ccccc1Cc1nc2ccc(cc2[nH]1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(CC2)C(=O)N(C)C)c2ncnc(N)c12 |r,wU:24.30,wD:21.23,(8.83,13.92,;7.49,13.15,;7.49,11.61,;8.83,10.84,;8.83,9.3,;7.49,8.53,;6.16,9.3,;6.16,10.84,;4.72,11.39,;3.53,10.41,;2.04,10.8,;1.21,9.5,;-.31,9.25,;-.85,7.81,;.12,6.62,;1.64,6.87,;2.19,8.31,;3.62,8.87,;-.35,5.15,;.55,3.91,;-.35,2.66,;.42,1.33,;-.41,.03,;.29,-1.34,;1.83,-1.41,;2.66,-.11,;1.96,1.26,;2.6,-2.74,;1.94,-4.13,;2.81,-5.4,;4.35,-5.28,;5.01,-3.89,;4.14,-2.62,;5.22,-6.55,;6.75,-6.43,;4.55,-7.94,;4.55,-9.48,;3.05,-7.6,;-1.82,3.14,;-3.15,2.37,;-4.48,3.14,;-4.48,4.68,;-3.15,5.45,;-3.15,6.99,;-1.82,4.68,)| Show InChI InChI=1S/C33H40N10O2/c1-40(2)33(44)42-16-14-41(15-17-42)23-9-11-24(12-10-23)43-32-29(31(34)35-20-36-32)30(39-43)22-8-13-25-26(18-22)38-28(37-25)19-21-6-4-5-7-27(21)45-3/h4-8,13,18,20,23-24H,9-12,14-17,19H2,1-3H3,(H,37,38)(H2,34,35,36)/t23-,24-	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	7.5	23
Abbott Laboratories					Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ...				Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17534 (2-{[2-({[2-(diethylamino)ethyl]carbamoyl}amino)ben...) Show SMILES CCN(CC)CCNC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H32N4O5S/c1-3-28(4-2)16-15-25-24(31)26-19-11-7-8-12-21(19)34(32,33)27-20-14-13-17-9-5-6-10-18(17)22(20)23(29)30/h7-8,11-14,27H,3-6,9-10,15-16H2,1-2H3,(H,29,30)(H2,25,26,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17497 (2-[(2-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}ben...) Show SMILES CN1CCCC1CCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H31N3O4S/c1-27-16-6-8-18(27)14-15-25-20-10-4-5-11-22(20)32(30,31)26-21-13-12-17-7-2-3-9-19(17)23(21)24(28)29/h4-5,10-13,18,25-26H,2-3,6-9,14-16H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17502 (2-({2-[(piperidin-4-ylmethyl)amino]benzene}sulfona...) Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCC2CCNCC2)ccc2CCCCc12 Show InChI InChI=1S/C23H29N3O4S/c27-23(28)22-18-6-2-1-5-17(18)9-10-20(22)26-31(29,30)21-8-4-3-7-19(21)25-15-16-11-13-24-14-12-16/h3-4,7-10,16,24-26H,1-2,5-6,11-15H2,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17496 (2-[(2-{[3-(pyrrolidin-1-yl)propyl]amino}benzene)su...) Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCCC2)ccc2CCCCc12 Show InChI InChI=1S/C24H31N3O4S/c28-24(29)23-19-9-2-1-8-18(19)12-13-21(23)26-32(30,31)22-11-4-3-10-20(22)25-14-7-17-27-15-5-6-16-27/h3-4,10-13,25-26H,1-2,5-9,14-17H2,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50315887 ((1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidaz...) Show SMILES C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12 |r,wU:1.1,4.6,wD:1.0,(18.42,-37.26,;17.1,-36.49,;16.31,-37.82,;17.79,-35.11,;16.41,-34.42,;15.72,-35.8,;15.93,-32.97,;16.83,-31.71,;15.91,-30.47,;16.38,-29.01,;15.35,-27.88,;15.81,-26.41,;17.32,-26.08,;17.78,-24.62,;19.27,-24.29,;20.31,-25.42,;19.85,-26.89,;18.35,-27.21,;17.89,-28.68,;21.81,-25.09,;22.85,-26.23,;24.35,-25.9,;24.82,-24.43,;23.77,-23.29,;22.27,-23.63,;14.45,-30.96,;13.11,-30.19,;13.11,-28.65,;11.78,-30.96,;11.78,-32.51,;13.12,-33.28,;14.46,-32.5,)| Show InChI InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)/t19-,26+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant IGF1R expressed in Sf21 cells by time resolved fluorescence assay				Bioorg Med Chem Lett 20: 2452-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.015 BindingDB Entry DOI: 10.7270/Q2M908VT
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17486 (2-{[2-({2-[(dimethylamino)methyl]-2-methylpropyl}a...) Show SMILES CN(C)CC(C)(C)CNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H33N3O4S/c1-24(2,16-27(3)4)15-25-19-11-7-8-12-21(19)32(30,31)26-20-14-13-17-9-5-6-10-18(17)22(20)23(28)29/h7-8,11-14,25-26H,5-6,9-10,15-16H2,1-4H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17570 (2-({2-[(1Z)-3-(4-methylpiperazin-1-yl)prop-1-en-1-...) Show SMILES CN1CCN(C\C=C/c2ccccc2S(=O)(=O)Nc2ccc3CCCCc3c2C(O)=O)CC1 Show InChI InChI=1S/C25H31N3O4S/c1-27-15-17-28(18-16-27)14-6-9-20-8-3-5-11-23(20)33(31,32)26-22-13-12-19-7-2-4-10-21(19)24(22)25(29)30/h3,5-6,8-9,11-13,26H,2,4,7,10,14-18H2,1H3,(H,29,30)/b9-6-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (Homo sapiens (Human))	BDBM50315888 (CHEMBL1090360 | N-(3-(5-(2-(3-morpholinophenylamin...) Show SMILES O=C(Cc1ccccc1)Nc1cccc(c1)-c1nc2sccn2c1-c1ccnc(Nc2cccc(c2)N2CCOCC2)n1 Show InChI InChI=1S/C33H29N7O2S/c41-29(20-23-6-2-1-3-7-23)35-25-9-4-8-24(21-25)30-31(40-16-19-43-33(40)38-30)28-12-13-34-32(37-28)36-26-10-5-11-27(22-26)39-14-17-42-18-15-39/h1-13,16,19,21-22H,14-15,17-18,20H2,(H,35,41)(H,34,36,37)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of ErRB4				Bioorg Med Chem Lett 20: 2452-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.015 BindingDB Entry DOI: 10.7270/Q2M908VT
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17565 (2-({2-[(1Z)-3-(diethylamino)but-1-en-1-yl]benzene}...) Show SMILES CCN(CC)C(C)\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C25H32N2O4S/c1-4-27(5-2)18(3)14-15-20-11-7-9-13-23(20)32(30,31)26-22-17-16-19-10-6-8-12-21(19)24(22)25(28)29/h7,9,11,13-18,26H,4-6,8,10,12H2,1-3H3,(H,28,29)/b15-14-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17572 (2-({2-[(1Z)-3-(dimethylamino)prop-1-en-1-yl]-4-flu...) Show SMILES CN(C)C\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C22H25FN2O4S/c1-25(2)13-5-7-16-14-17(23)10-12-20(16)30(28,29)24-19-11-9-15-6-3-4-8-18(15)21(19)22(26)27/h5,7,9-12,14,24H,3-4,6,8,13H2,1-2H3,(H,26,27)/b7-5-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17510 (2-[(2-{[3-(diethylamino)propyl]amino}-6-fluorobenz...) Show SMILES CCN(CC)CCCNc1cccc(F)c1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C24H32FN3O4S/c1-3-28(4-2)16-8-15-26-21-12-7-11-19(25)23(21)33(31,32)27-20-14-13-17-9-5-6-10-18(17)22(20)24(29)30/h7,11-14,26-27H,3-6,8-10,15-16H2,1-2H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17603 (2-benzenesulfonamidonaphthalene-1-carboxylic acid ...) Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2)ccc2ccccc12 Show InChI InChI=1S/C17H13NO4S/c19-17(20)16-14-9-5-4-6-12(14)10-11-15(16)18-23(21,22)13-7-2-1-3-8-13/h1-11,18H,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				Bioorg Med Chem Lett 16: 3574-7 (2006) Article DOI: 10.1016/j.bmcl.2006.03.085 BindingDB Entry DOI: 10.7270/Q2TB1556
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17581 (2-({2-[4-(diethylamino)butyl]benzene}sulfonamido)-...) Show SMILES CCN(CC)CCCCc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O Show InChI InChI=1S/C25H34N2O4S/c1-3-27(4-2)18-10-9-13-20-12-6-8-15-23(20)32(30,31)26-22-17-16-19-11-5-7-14-21(19)24(22)25(28)29/h6,8,12,15-17,26H,3-5,7,9-11,13-14,18H2,1-2H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	25
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...				J Med Chem 49: 3832-49 (2006) Article DOI: 10.1021/jm0601001 BindingDB Entry DOI: 10.7270/Q22V2DDZ
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM50141730 ((2S,3R)-3-Amino-5-ethylsulfanyl-2-hydroxy-pentanoi...) Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)N(C)Cc1cccc2ccccc12 Show InChI InChI=1S/C19H26N2O2S/c1-3-24-12-11-17(20)18(22)19(23)21(2)13-15-9-6-8-14-7-4-5-10-16(14)15/h4-10,17-18,22H,3,11-13,20H2,1-2H3/t17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-2				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
					More data for this Ligand-Target Pair
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM50141759 ((R)-3-Amino-2-hydroxy-5-phenyl-pentanoic acid ((S)...) Show SMILES C[C@H](NC(=O)[C@@H](O)[C@H](N)CCc1ccccc1)c1cccc2ccccc12 Show InChI InChI=1S/C23H26N2O2/c1-16(19-13-7-11-18-10-5-6-12-20(18)19)25-23(27)22(26)21(24)15-14-17-8-3-2-4-9-17/h2-13,16,21-22,26H,14-15,24H2,1H3,(H,25,27)/t16-,21+,22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-2				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
					More data for this Ligand-Target Pair

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