| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50150536 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305167 (CHEMBL832757) |
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| IC50 | 54±n/a nM |
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| Citation |  Robichaud, J; Bayly, C; Oballa, R; Prasit, P; Mellon, C; Falgueyret, JP; Percival, MD; Wesolowski, G; Rodan, SB Rational design of potent and selective NH-linked aryl/heteroaryl cathepsin K inhibitors. Bioorg Med Chem Lett14:4291-5 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_RABIT | CTSK |
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| Type: | Enzyme |
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| Mol. Mass.: | 36879.51 |
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| Organism: | Oryctolagus cuniculus (rabbit) |
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| Description: | n/a |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50150536 |
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| n/a |
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| Name | BDBM50150536 |
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| Synonyms: | 2-(2-Bromo-phenylamino)-4-methyl-pentanoic acid cyanomethyl-amide | CHEMBL184828 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18BrN3O |
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| Mol. Mass. | 324.216 |
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| SMILES | CC(C)CC(Nc1ccccc1Br)C(=O)NCC#N |
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| Structure | 
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