Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50582458 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2154640 (CHEMBL5039300) |
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IC50 | 580±n/a nM |
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Citation | Duan, YC; Jin, LF; Ren, HM; Zhang, SJ; Liu, YJ; Xu, YT; He, ZH; Song, Y; Yuan, H; Chen, SH; Guan, YY Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer. Eur J Med Chem220:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50582458 |
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n/a |
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Name | BDBM50582458 |
Synonyms: | CHEMBL5083395 |
Type | Small organic molecule |
Emp. Form. | C19H15N3O2 |
Mol. Mass. | 317.3413 |
SMILES | ONC(=O)c1ccc(\C=C\c2ccnc(c2)-c2cccnc2)cc1 |
Structure |
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