| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
|---|
| Ligand | BDBM50583918 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2158412 (CHEMBL5043162) |
|---|
| IC50 | 78±n/a nM |
|---|
| Citation |  Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7. J Med Chem65:1458-1480 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
|---|
| Name: | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
|---|
| Synonyms: | CDK2/CycE | CDK2/Cyclin E | CDK2/E | CDK2/E1 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-dependent kinase 2/G1/S-specific cyclin E1 | Cyclin-dependent kinase 2/cyclin E1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 2 |
|---|
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33938.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P24941 |
|---|
| Residue: | 298 |
|---|
| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
|
|
|
|---|
| Component 2 |
| Name: | G1/S-specific cyclin-E1 |
|---|
| Synonyms: | CCNE | CCNE1 | CCNE1_HUMAN |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 47073.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 410 |
|---|
| Sequence: | MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
|
|
|
|---|
| BDBM50583918 |
|---|
| n/a |
|---|
| Name | BDBM50583918 |
|---|
| Synonyms: | CHEMBL4791134 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20F3N5O2S |
|---|
| Mol. Mass. | 439.455 |
|---|
| SMILES | CS(=O)(=O)c1cccc2c(c[nH]c12)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
