| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
|---|
| Ligand | BDBM50585893 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2164245 (CHEMBL5049106) |
|---|
| IC50 | 310±n/a nM |
|---|
| Citation |  Tanaka, Y; Seto, M; Kakegawa, K; Takami, K; Kikuchi, F; Yamamoto, T; Nakamura, M; Daini, M; Murakami, M; Ohashi, T; Kasahara, T; Wang, J; Ikeda, Z; Wada, Y; Puenner, F; Fujii, T; Inazuka, M; Sato, S; Suzaki, T; Oak, JH; Takai, Y; Kohara, H; Kimoto, K; Oki, H; Mikami, S; Sasaki, M; Tanaka, Y Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem65:4270-4290 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent serotonin transporter |
|---|
| Name: | Sodium-dependent serotonin transporter |
|---|
| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 70322.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31645 |
|---|
| Residue: | 630 |
|---|
| Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
|
|
|
|---|
| BDBM50585893 |
|---|
| n/a |
|---|
| Name | BDBM50585893 |
|---|
| Synonyms: | CHEMBL5078078 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H20F4N2O3 |
|---|
| Mol. Mass. | 460.4208 |
|---|
| SMILES | CC(C)(O)c1ccc(cc1)N1Cc2c(ccnc2-c2ccc(F)cc2OCC(F)(F)F)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
