Reaction Details |
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Target | Ceramide glucosyltransferase |
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Ligand | BDBM50585893 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2164248 (CHEMBL5049109) |
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EC50 | 7.6±n/a nM |
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Citation | Tanaka, Y; Seto, M; Kakegawa, K; Takami, K; Kikuchi, F; Yamamoto, T; Nakamura, M; Daini, M; Murakami, M; Ohashi, T; Kasahara, T; Wang, J; Ikeda, Z; Wada, Y; Puenner, F; Fujii, T; Inazuka, M; Sato, S; Suzaki, T; Oak, JH; Takai, Y; Kohara, H; Kimoto, K; Oki, H; Mikami, S; Sasaki, M; Tanaka, Y Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem65:4270-4290 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ceramide glucosyltransferase |
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Name: | Ceramide glucosyltransferase |
Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
Type: | PROTEIN |
Mol. Mass.: | 44859.25 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1435474 |
Residue: | 394 |
Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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BDBM50585893 |
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n/a |
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Name | BDBM50585893 |
Synonyms: | CHEMBL5078078 |
Type | Small organic molecule |
Emp. Form. | C24H20F4N2O3 |
Mol. Mass. | 460.4208 |
SMILES | CC(C)(O)c1ccc(cc1)N1Cc2c(ccnc2-c2ccc(F)cc2OCC(F)(F)F)C1=O |
Structure |
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