Reaction Details |
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Target | BDNF/NT-3 growth factors receptor |
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Ligand | BDBM50579500 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2168767 (CHEMBL5053826) |
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IC50 | 1.8±n/a nM |
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Citation | Li, MC; Lin, WH; Wang, PC; Su, YC; Chen, PY; Fan, CM; Chen, CP; Huang, CL; Chiu, CH; Chang, L; Chen, CT; Yeh, TK; Hsieh, HP Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization. Eur J Med Chem224:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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BDNF/NT-3 growth factors receptor |
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Name: | BDNF/NT-3 growth factors receptor |
Synonyms: | GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B) |
Type: | Enzyme |
Mol. Mass.: | 91996.87 |
Organism: | Homo sapiens (Human) |
Description: | Q16620 |
Residue: | 822 |
Sequence: | MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL
KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI
VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI
AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM
PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ
EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
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BDBM50579500 |
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n/a |
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Name | BDBM50579500 |
Synonyms: | CHEMBL4864729 |
Type | Small organic molecule |
Emp. Form. | C25H28ClN7O2S |
Mol. Mass. | 526.054 |
SMILES | CN(C)CCCOc1ccc2c(NCCc3cnc(NC(=O)Nc4cccc(Cl)c4)s3)ncnc2c1 |
Structure |
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