| Reaction Details |
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 | Report a problem with these data |
| Target | NT-3 growth factor receptor |
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| Ligand | BDBM50579500 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2168768 (CHEMBL5053827) |
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| IC50 | 0.210000±n/a nM |
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| Citation |  Li, MC; Lin, WH; Wang, PC; Su, YC; Chen, PY; Fan, CM; Chen, CP; Huang, CL; Chiu, CH; Chang, L; Chen, CT; Yeh, TK; Hsieh, HP Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization. Eur J Med Chem224:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NT-3 growth factor receptor |
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| Name: | NT-3 growth factor receptor |
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| Synonyms: | GP145-TrkC | NTRK3 | NTRK3_HUMAN | Neurotrophic tyrosine kinase receptor | Neurotrophic tyrosine kinase receptor type 3 | TRKC | Trk-C | TrkC tyrosine kinase | Tyrosine kinase receptor C (Trk-C) |
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| Type: | Enzyme |
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| Mol. Mass.: | 94428.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16288 |
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| Residue: | 839 |
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| Sequence: | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF
CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
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| BDBM50579500 |
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| n/a |
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| Name | BDBM50579500 |
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| Synonyms: | CHEMBL4864729 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28ClN7O2S |
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| Mol. Mass. | 526.054 |
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| SMILES | CN(C)CCCOc1ccc2c(NCCc3cnc(NC(=O)Nc4cccc(Cl)c4)s3)ncnc2c1 |
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| Structure | 
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