| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM19746 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306405 (CHEMBL828746) |
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| IC50 | 89±n/a nM |
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| Citation |  Altmann, E; Cowan-Jacob, SW; Missbach, M Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. J Med Chem47:5833-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM19746 |
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| n/a |
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| Name | BDBM19746 |
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| Synonyms: | 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)ethyl]-9H-purine-2-carbonitrile | CHEMBL363847 | NVP-ABE854 | Purine lead structure, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28N8 |
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| Mol. Mass. | 368.4792 |
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| SMILES | CN1CCN(CCn2cnc3c(NC4CCCCC4)nc(nc23)C#N)CC1 |
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| Structure | 
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