Reaction Details |
| Report a problem with these data |
Target | Bifunctional epoxide hydrolase 2 |
---|
Ligand | BDBM50586953 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2170254 (CHEMBL5055313) |
---|
IC50 | 43±n/a nM |
---|
Citation | Lillich, FF; Willems, S; Ni, X; Kilu, W; Borkowsky, C; Brodsky, M; Kramer, JS; Brunst, S; Hernandez-Olmos, V; Heering, J; Schierle, S; Kestner, RI; Mayser, FM; Helmstädter, M; Göbel, T; Weizel, L; Namgaladze, D; Kaiser, A; Steinhilber, D; Pfeilschifter, W; Kahnt, AS; Proschak, A; Chaikuad, A; Knapp, S; Merk, D; Proschak, E Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor ? Agonists/Soluble Epoxide Hydrolase Inhibitors. J Med Chem64:17259-17276 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Bifunctional epoxide hydrolase 2 |
---|
Name: | Bifunctional epoxide hydrolase 2 |
Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
Type: | Enzyme |
Mol. Mass.: | 62613.07 |
Organism: | Homo sapiens (Human) |
Description: | P34913 |
Residue: | 555 |
Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
|
|
|
BDBM50586953 |
---|
n/a |
---|
Name | BDBM50586953 |
Synonyms: | CHEMBL5085618 |
Type | Small organic molecule |
Emp. Form. | C19H17F3N2O3S |
Mol. Mass. | 410.41 |
SMILES | CS(=O)(=O)Cc1ccc(CNC(=O)c2ccc3[nH]ccc3c2)c(c1)C(F)(F)F |
Structure |
|