Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM50589740 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2194219 (CHEMBL5106579) |
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Ki | >10000±n/a nM |
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Citation | Drennen, B; Goodis, CC; Bowen, N; Yu, W; Vickers, G; Wilder, PT; MacKerell, AD; Fletcher, S Scaffold hopping from indoles to indazoles yields dual MCL-1/BCL-2 inhibitors from MCL-1 selective leads. RSC Med Chem13:963-969 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM50589740 |
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n/a |
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Name | BDBM50589740 |
Synonyms: | CHEMBL5192657 |
Type | Small organic molecule |
Emp. Form. | C35H28Cl2N6O6S |
Mol. Mass. | 731.604 |
SMILES | Cc1cc(Oc2ccc(Cn3nc4ccc(Cl)cc4c3C(=O)NS(=O)(=O)c3ccc(c(NCc4ccncc4)c3)[N+]([O-])=O)cc2)cc(C)c1Cl |
Structure |
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