| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
|---|
| Ligand | BDBM50143926 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305688 (CHEMBL828060) |
|---|
| IC50 | 370±n/a nM |
|---|
| Citation |  Kim, IH; Heirtzler, FR; Morisseau, C; Nishi, K; Tsai, HJ; Hammock, BD Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem48:3621-9 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional epoxide hydrolase 2 |
|---|
| Name: | Bifunctional epoxide hydrolase 2 |
|---|
| Synonyms: | Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62512.06 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P34914 |
|---|
| Residue: | 554 |
|---|
| Sequence: | MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITF
SQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTC
IVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYV
TVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPF
MPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHK
ATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLG
RKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKW
LQTEVQNPSVTSKI
|
|
|
|---|
| BDBM50143926 |
|---|
| n/a |
|---|
| Name | BDBM50143926 |
|---|
| Synonyms: | 4-[3-(3-Chloro-phenyl)-ureido]-butyric acid pentyl ester | CHEMBL418331 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H23ClN2O3 |
|---|
| Mol. Mass. | 326.818 |
|---|
| SMILES | CCCCCOC(=O)CCCNC(=O)Nc1cccc(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
