| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM50595799 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2218054 (CHEMBL5131186) |
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| IC50 | 1200±n/a nM |
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| Citation |  Sokolsky, A; Winterton, S; Kennedy, K; Drake, K; Stump, K; Huo, L; Lo, Y; Ye, M; Covington, M; Diamond, S; Yang, YO; Kim, S; Yeleswaram, S; Wu, L; Yao, W Discovery of 5,7-Dihydro-6 ACS Med Chem Lett13:1797-1804 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM50595799 |
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| n/a |
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| Name | BDBM50595799 |
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| Synonyms: | CHEMBL5186159 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N5O3S |
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| Mol. Mass. | 399.467 |
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| SMILES | NS(=O)(=O)c1ccc(Nc2ncc3c(n2)N(C2CCCC2)C(=O)C32CC2)cc1 |
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| Structure | 
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