| Reaction Details |
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 | Report a problem with these data |
| Target | Pyruvate kinase PKM |
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| Ligand | BDBM50597699 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2224224 (CHEMBL5137737) |
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| EC50 | <100±n/a nM |
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| Citation |  Arora, S; Joshi, G; Chaturvedi, A; Heuser, M; Patil, S; Kumar, R A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2. J Med Chem65:1171-1205 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pyruvate kinase PKM |
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| Name: | Pyruvate kinase PKM |
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| Synonyms: | KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2) |
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| Type: | Protein |
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| Mol. Mass.: | 57944.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14618 |
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| Residue: | 531 |
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| Sequence: | MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
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| BDBM50597699 |
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| n/a |
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| Name | BDBM50597699 |
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| Synonyms: | CHEMBL5170943 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24F2N4O3S |
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| Mol. Mass. | 524.579 |
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| SMILES | [2H]C([2H])(N1CCN(CC1)C(=O)c1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1)c1cc(F)cc(F)c1 |
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| Structure | 
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