| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase 2 |
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| Ligand | BDBM50174781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326856 (CHEMBL860455) |
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| IC50 | 96±n/a nM |
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| Citation |  Birch, HL; Buckley, GM; Davies, N; Dyke, HJ; Frost, EJ; Gilbert, PJ; Hannah, DR; Haughan, AF; Madigan, MJ; Morgan, T; Pitt, WR; Ratcliffe, AJ; Ray, NC; Richard, MD; Sharpe, A; Taylor, AJ; Whitworth, JM; Williams, SC Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors. Bioorg Med Chem Lett15:5335-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase 2 |
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| Name: | Inosine-5'-monophosphate dehydrogenase 2 |
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| Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55806.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant IMPDH2 expressed in E. coli. |
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| Residue: | 514 |
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| Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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| BDBM50174781 |
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| n/a |
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| Name | BDBM50174781 |
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| Synonyms: | 7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-3',4',1,3-tetrahydro-1'H-spiro[cyclopenta[b]thiophene-2,2'-quinazoline]-4'-one | CHEMBL197546 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17N3O3S |
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| Mol. Mass. | 367.422 |
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| SMILES | COc1cc2NC3(Cc4ccsc4C3)N(C)C(=O)c2cc1-c1cnco1 |
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| Structure | 
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