Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174864

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

2±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174864

n/a

Name

BDBM50174864

Synonyms:

CHEMBL200614 | X2-Apc-DPhe-Arg-Trp-Z3-NH2

Type

Small organic molecule

Emp. Form.

C47H63N11O6

Mol. Mass.

878.0732

SMILES

CCCCNC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(N)=O |wU:34.36,11.14,23.24,59.64,8.7,wD:8.21,45.47,(-3.29,-37.32,;-1.95,-36.55,;-.63,-37.32,;.71,-36.55,;2.03,-37.32,;3.37,-36.54,;3.37,-35.01,;4.7,-37.32,;6.04,-36.54,;7.38,-35.78,;7.38,-34.25,;6.05,-33.47,;4.72,-34.24,;4.72,-35.78,;6.06,-31.94,;7.4,-31.18,;7.4,-29.65,;6.08,-28.87,;4.74,-29.64,;4.74,-31.18,;7.37,-37.32,;7.37,-38.86,;8.71,-36.54,;10.05,-37.32,;10.05,-38.86,;11.39,-39.63,;11.38,-41.18,;12.72,-41.94,;14.05,-41.18,;14.05,-39.63,;12.71,-38.86,;11.39,-36.54,;11.39,-35.01,;12.72,-37.32,;14.06,-36.54,;14.06,-35.01,;15.4,-34.23,;15.4,-32.68,;16.73,-31.92,;16.73,-30.37,;18.07,-29.59,;15.4,-29.59,;15.4,-37.32,;15.4,-38.86,;16.73,-36.54,;18.07,-37.32,;18.07,-38.86,;19.41,-39.63,;20.76,-38.85,;21.86,-40.14,;21.09,-41.48,;21.57,-42.95,;20.54,-44.09,;19.02,-43.77,;18.55,-42.3,;19.58,-41.16,;19.41,-36.54,;19.41,-35.01,;20.75,-37.32,;22.08,-36.54,;22.07,-35,;23.42,-37.3,;24.74,-36.53,;23.42,-38.84,)|

Structure