Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174871

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

1±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174871

n/a

Name

BDBM50174871

Synonyms:

CHEMBL372201 | X1-Apc-DPhe-Arg-Trp-Z10-NH2

Type

Small organic molecule

Emp. Form.

C51H62N10O6

Mol. Mass.

911.1014

SMILES

CCCC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(cc1)C(N)=O |wU:32.34,9.12,21.22,6.5,wD:6.19,43.45,(-1.97,-35.98,;-.64,-35.21,;.69,-35.98,;2.02,-35.21,;2.02,-33.66,;3.36,-35.98,;4.7,-35.21,;6.04,-34.44,;6.04,-32.91,;4.71,-32.14,;3.38,-32.9,;3.37,-34.44,;4.72,-30.61,;6.06,-29.85,;6.06,-28.31,;4.73,-27.54,;3.4,-28.31,;3.4,-29.84,;6.03,-35.98,;6.03,-37.52,;7.37,-35.21,;8.71,-35.98,;8.71,-37.52,;10.04,-38.3,;10.03,-39.84,;11.37,-40.61,;12.71,-39.84,;12.7,-38.29,;11.37,-37.52,;10.04,-35.21,;10.04,-33.66,;11.38,-35.98,;12.72,-35.21,;12.72,-33.66,;14.05,-32.89,;14.05,-31.34,;15.39,-30.58,;15.39,-29.03,;16.73,-28.26,;14.05,-28.26,;14.05,-35.98,;14.05,-37.52,;15.39,-35.21,;16.73,-35.98,;16.73,-37.52,;18.07,-38.3,;19.41,-37.51,;20.52,-38.81,;19.75,-40.15,;20.22,-41.61,;19.19,-42.76,;17.67,-42.44,;17.2,-40.97,;18.24,-39.82,;18.07,-35.21,;18.07,-33.66,;19.41,-35.98,;20.73,-35.2,;22.07,-35.97,;22.06,-37.51,;23.39,-38.27,;24.72,-37.5,;24.71,-35.96,;23.38,-35.2,;26.05,-38.26,;27.38,-37.49,;26.06,-39.8,)|

Structure