Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174872

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

39±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174872

n/a

Name

BDBM50174872

Synonyms:

Bu-Apc-DPhe-Arg-2-Nal-Z9-NH2 | CHEMBL200668

Type

Small organic molecule

Emp. Form.

C52H61N9O6

Mol. Mass.

908.0974

SMILES

CCCC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)Nc1ccccc1C(N)=O |wU:32.34,9.12,6.5,21.22,wD:6.19,(-8.1,-31.02,;-6.75,-30.25,;-5.44,-31.03,;-4.09,-30.25,;-4.09,-28.72,;-2.76,-31.03,;-1.42,-30.26,;-.08,-29.5,;-.08,-27.97,;-1.4,-27.19,;-2.74,-27.96,;-2.75,-29.5,;-1.4,-25.67,;-.06,-24.9,;-.06,-23.37,;-1.38,-22.59,;-2.72,-23.36,;-2.72,-24.9,;-.09,-31.03,;-.09,-32.57,;1.26,-30.25,;2.59,-31.03,;2.59,-32.57,;3.92,-33.35,;3.91,-34.89,;5.24,-35.65,;6.59,-34.89,;6.58,-33.34,;5.25,-32.57,;3.92,-30.25,;3.92,-28.72,;5.25,-31.03,;6.59,-30.25,;6.59,-28.72,;7.93,-27.94,;7.93,-26.4,;9.27,-25.63,;9.27,-24.09,;10.6,-23.31,;7.93,-23.31,;7.93,-31.03,;7.93,-32.57,;9.27,-30.25,;10.6,-31.03,;10.6,-32.57,;11.94,-33.35,;13.27,-32.57,;14.6,-33.35,;14.61,-34.89,;15.94,-35.67,;15.93,-37.21,;14.59,-37.98,;13.25,-37.21,;13.26,-35.66,;11.93,-34.89,;11.94,-30.25,;11.94,-28.72,;13.27,-31.03,;14.61,-30.26,;14.6,-28.73,;15.93,-27.95,;17.27,-28.73,;17.27,-30.27,;15.94,-31.04,;15.93,-32.57,;17.41,-32.98,;15.15,-33.9,)|

Structure