Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174875

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_326975 (CHEMBL868738)

EC50

15±n/a nM

Citation

Cheung, AW; Qi, L; Gore, V; Chu, XJ; Bartkovitz, D; Kurylko, G; Swistok, J; Danho, W; Chen, L; Yagaloff, K Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2. Bioorg Med Chem Lett15:5504-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174875

n/a

Name

BDBM50174875

Synonyms:

CHEMBL414670 | X2-5-BrAtc-DPhe-Arg-Trp-Z9-NH2

Type

Small organic molecule

Emp. Form.

C49H58BrN11O6

Mol. Mass.

976.959

SMILES

CCCCNC(=O)NC1(CCc2c(Br)cccc2C1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccccc1C(N)=O |wU:33.35,22.23,wD:44.46,(-12.69,-41.5,;-11.35,-40.73,;-10.02,-41.49,;-8.68,-40.73,;-7.36,-41.49,;-6.03,-40.72,;-6.03,-39.17,;-4.69,-41.49,;-3.34,-40.72,;-2.01,-39.95,;-2,-38.43,;-3.33,-37.65,;-3.34,-36.12,;-2,-35.37,;-4.66,-35.36,;-5.99,-36.13,;-5.98,-37.65,;-4.67,-38.41,;-4.67,-39.96,;-2.01,-41.49,;-2.01,-43.03,;-.68,-40.72,;.67,-41.49,;.67,-43.03,;1.99,-43.81,;1.98,-45.35,;3.32,-46.12,;4.66,-45.35,;4.66,-43.81,;3.32,-43.03,;1.99,-40.72,;1.99,-39.17,;3.33,-41.49,;4.67,-40.72,;4.67,-39.17,;6,-38.41,;6,-36.86,;7.35,-36.1,;7.35,-34.55,;8.68,-33.77,;6,-33.77,;6,-41.49,;6,-43.03,;7.35,-40.72,;8.68,-41.49,;8.68,-43.03,;10.02,-43.81,;11.36,-43.03,;12.46,-44.32,;11.69,-45.66,;12.17,-47.12,;11.14,-48.27,;9.63,-47.95,;9.15,-46.48,;10.19,-45.34,;10.02,-40.72,;10.02,-39.17,;11.36,-41.49,;12.68,-40.72,;13.43,-42.06,;14.96,-42.08,;15.74,-40.75,;14.98,-39.41,;13.45,-39.4,;12.69,-38.07,;13.47,-36.74,;11.16,-38.06,)|

Structure