| Reaction Details |
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 | Report a problem with these data |
| Target | B2 bradykinin receptor |
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| Ligand | BDBM50182454 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_333385 (CHEMBL859129) |
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| Ki | >10000±n/a nM |
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| Citation |  Wood, MR; Schirripa, KM; Kim, JJ; Wan, BL; Murphy, KL; Ransom, RW; Chang, RS; Tang, C; Prueksaritanont, T; Detwiler, TJ; Hettrick, LA; Landis, ER; Leonard, YM; Krueger, JA; Lewis, SD; Pettibone, DJ; Freidinger, RM; Bock, MG Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine. Application to the design of novel bradykinin B1 receptor antagonists. J Med Chem49:1231-4 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B2 bradykinin receptor |
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| Name: | B2 bradykinin receptor |
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| Synonyms: | B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44467.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | B2 BRADYKININ BDKRB2 HUMAN::P30411 |
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| Residue: | 391 |
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| Sequence: | MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
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| BDBM50182454 |
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| n/a |
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| Name | BDBM50182454 |
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| Synonyms: | CHEMBL201107 | methyl 4'-{[({1-[(3,3,3-trifluoropropanoyl)amino]cyclohexyl}carbonyl)amino]methyl}-1,1'-biphenyl-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27F3N2O4 |
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| Mol. Mass. | 476.4881 |
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| SMILES | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(CCCCC2)NC(=O)CC(F)(F)F)cc1 |
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| Structure | 
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