Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Inosine-5'-monophosphate dehydrogenase 2 |
---|
Ligand | BDBM50182920 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_351089 (CHEMBL866272) |
---|
IC50 | 84±n/a nM |
---|
Citation | Beevers, RE; Buckley, GM; Davies, N; Fraser, JL; Galvin, FC; Hannah, DR; Haughan, AF; Jenkins, K; Mack, SR; Pitt, WR; Ratcliffe, AJ; Richard, MD; Sabin, V; Sharpe, A; Williams, SC Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett16:2539-42 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Inosine-5'-monophosphate dehydrogenase 2 |
---|
Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
|
|
|
BDBM50182920 |
---|
n/a |
---|
Name | BDBM50182920 |
Synonyms: | 1-methyl-1-phenyl-3-(3-(pyridin-4-yl)-1H-indol-6-yl)urea | CHEMBL206886 |
Type | Small organic molecule |
Emp. Form. | C21H18N4O |
Mol. Mass. | 342.3938 |
SMILES | CN(C(=O)Nc1ccc2c(c[nH]c2c1)-c1ccncc1)c1ccccc1 |
Structure |
|