| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 3 |
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| Ligand | BDBM50604152 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2247094 (CHEMBL5161304) |
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| IC50 | >100000±n/a nM |
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| Citation |  Qiao, Y; Zhang, Y; Qiao, Z; He, W; Chen, Y; Song, D; Wang, G; Guo, N; Shao, L; Tian, Z; Wang, Q; Yan, L; Qian, H Discovery of (S)-N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist. Eur J Med Chem233:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily V member 3 |
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| Name: | Transient receptor potential cation channel subfamily V member 3 |
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| Synonyms: | TRPV3 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3) | Vanilloid receptor-like 3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 90635.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8NET8 |
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| Residue: | 790 |
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| Sequence: | MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS
PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK
KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN
PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD
VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL
HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI
LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML
TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG
WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY
LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG
FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT
YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL
CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE
EVEEFPETSV
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| BDBM50604152 |
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| n/a |
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| Name | BDBM50604152 |
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| Synonyms: | CHEMBL5181908 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N3OS |
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| Mol. Mass. | 391.529 |
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| SMILES | CC(C)c1cccc(NC(=O)N2CCC[C@H]2c2ncc(s2)-c2ccccc2)c1 |r| |
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| Structure | 
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