Reaction Details |
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Target | C-C chemokine receptor type 2 |
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Ligand | BDBM50187031 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_375682 (CHEMBL863683) |
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IC50 | 424±n/a nM |
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Citation | Yang, L; Zhou, C; Guo, L; Morriello, G; Butora, G; Pasternak, A; Parsons, WH; Mills, SG; MacCoss, M; Vicario, PP; Zweerink, H; Ayala, JM; Goyal, S; Hanlon, WA; Cascieri, MA; Springer, MS Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists. Bioorg Med Chem Lett16:3735-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 2 |
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Name: | C-C chemokine receptor type 2 |
Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
Type: | Enzyme |
Mol. Mass.: | 41932.32 |
Organism: | Homo sapiens (Human) |
Description: | P41597 |
Residue: | 374 |
Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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BDBM50187031 |
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n/a |
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Name | BDBM50187031 |
Synonyms: | (S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylamino)-2-(thiophen-3-yl)acetamide | CHEMBL379818 |
Type | Small organic molecule |
Emp. Form. | C19H21F6N3OS |
Mol. Mass. | 453.445 |
SMILES | CN(C)CCN[C@H](C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ccsc1 |
Structure |
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