| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM50193750 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_424080 (CHEMBL855083) |
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| IC50 | 80±n/a nM |
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| Citation |  Hopkins, CR; O'neil, SV; Laufersweiler, MC; Wang, Y; Pokross, M; Mekel, M; Evdokimov, A; Walter, R; Kontoyianni, M; Petrey, ME; Sabatakos, G; Roesgen, JT; Richardson, E; Demuth, TP Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. Bioorg Med Chem Lett16:5659-63 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 57613.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37231 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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| BDBM50193750 |
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| n/a |
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| Name | BDBM50193750 |
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| Synonyms: | 1-(3-(trifluoromethyl)benzyl)-N-(3-(trifluoromethyl)phenylsulfonyl)-1H-indole-2-carboxamide | CHEMBL221342 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H16F6N2O3S |
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| Mol. Mass. | 526.451 |
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| SMILES | FC(F)(F)c1cccc(Cn2c(cc3ccccc23)C(=O)NS(=O)(=O)c2cccc(c2)C(F)(F)F)c1 |
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| Structure | 
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