| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor delta |
|---|
| Ligand | BDBM50194630 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_396486 (CHEMBL911540) |
|---|
| IC50 | 4±n/a nM |
|---|
| Citation |  Xu, Y; Etgen, GJ; Broderick, CL; Canada, E; Gonzalez, I; Lamar, J; Montrose-Rafizadeh, C; Oldham, BA; Osborne, JJ; Xie, C; Shi, Q; Winneroski, LL; York, J; Yumibe, N; Zink, R; Mantlo, N Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile. J Med Chem49:5649-52 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Peroxisome proliferator-activated receptor delta |
|---|
| Name: | Peroxisome proliferator-activated receptor delta |
|---|
| Synonyms: | NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49910.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q03181 |
|---|
| Residue: | 441 |
|---|
| Sequence: | MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
|
|
|
|---|
| BDBM50194630 |
|---|
| n/a |
|---|
| Name | BDBM50194630 |
|---|
| Synonyms: | (R)-3-{4-[3-(4-chloro-2-phenoxy-phenoxy)-butoxy]-2-ethyl-phenyl}-propionic acid | CHEMBL215701 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H29ClO5 |
|---|
| Mol. Mass. | 468.969 |
|---|
| SMILES | CCc1cc(OCC[C@@H](C)Oc2ccc(Cl)cc2Oc2ccccc2)ccc1CCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
