| Reaction Details |
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 | Report a problem with these data |
| Target | Insulin-degrading enzyme |
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| Ligand | BDBM50609677 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2279076 |
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| IC50 | 20000±n/a nM |
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| Citation |  Legru, A; Verdirosa, F; Vo-Hoang, Y; Tassone, G; Vascon, F; Thomas, CA; Sannio, F; Corsica, G; Benvenuti, M; Feller, G; Coulon, R; Marcoccia, F; Devente, SR; Bouajila, E; Piveteau, C; Leroux, F; Deprez-Poulain, R; Deprez, B; Licznar-Fajardo, P; Crowder, MW; Cendron, L; Pozzi, C; Mangani, S; Docquier, JD; Hernandez, JF; Gavara, L Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-?-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates. J Med Chem65:16392-16419 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Insulin-degrading enzyme |
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| Name: | Insulin-degrading enzyme |
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| Synonyms: | Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 117968.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14735 |
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| Residue: | 1019 |
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| Sequence: | MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
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| BDBM50609677 |
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| n/a |
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| Name | BDBM50609677 |
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| Synonyms: | CHEMBL5272558 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N8O2S |
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| Mol. Mass. | 452.533 |
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| SMILES | OC(=O)[C@H](CCCn1c(n[nH]c1=S)-c1ccccc1)N(Cc1c[nH]cn1)Cc1c[nH]cn1 |r| |
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| Structure | 
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