| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 4 |
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| Ligand | BDBM50612721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2289592 |
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| IC50 | 5140±n/a nM |
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| Citation |  Shim, S; Jeong, DU; Kim, H; Kim, CY; Park, H; Jin, Y; Kim, KM; Lee, HJ; Kim, DH; Bae, YS; Choi, Y Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's disease. Eur J Med Chem244:0 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 4 |
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| Name: | NADPH oxidase 4 |
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| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66954.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_792879 |
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| Residue: | 578 |
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| Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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| BDBM50612721 |
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| n/a |
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| Name | BDBM50612721 |
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| Synonyms: | CHEMBL5282886 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O3S |
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| Mol. Mass. | 383.464 |
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| SMILES | CN(CCO)c1ccc(\C=C2\N(C)C(=S)N(C2=O)c2ccccc2)c(O)c1 |
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| Structure | 
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