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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50203591 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_454261 (CHEMBL903444) | ||
| Ki | 2800±n/a nM | ||
| Citation |  Han, X; Civiello, R; Pin, SS; Burris, K; Balanda, LA; Knipe, J; Ren, S; Fiedler, T; Browman, KE; Macci, R; Taber, MT; Zhang, J; Dubowchik, GM An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes. Bioorg Med Chem Lett17:2026-30 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50203591 | |||
| n/a | |||
| Name | BDBM50203591 | ||
| Synonyms: | CHEMBL396821 | [8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a,7,8-tetraaza-cyclopenta[a]inden-3-ylmethyl]-methyl-(2-pyridin-2-yl-ethyl)-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27ClN6 | ||
| Mol. Mass. | 458.986 | ||
| SMILES | CN(CCc1ccccn1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 |(5.34,.35,;6.34,-.82,;7.85,-.56,;8.38,.89,;7.39,2.07,;5.89,1.8,;4.9,2.98,;5.43,4.43,;6.95,4.69,;7.93,3.51,;5.81,-2.27,;6.8,-3.44,;6.43,-4.94,;5.01,-5.52,;7.74,-5.75,;8.92,-4.76,;10.46,-4.65,;11.45,-5.84,;12.96,-5.57,;13.48,-4.12,;13.95,-6.74,;13.42,-8.2,;14.41,-9.37,;11.9,-8.46,;10.91,-7.28,;9.4,-7.54,;10.83,-3.17,;12.2,-2.44,;12.26,-.9,;10.88,-.01,;9.58,-.8,;9.52,-2.34,;8.34,-3.33,)| | ||
| Structure | 
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