| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
|---|
| Ligand | BDBM50224124 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_450438 (CHEMBL900722) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Biava, M; Porretta, GC; Poce, G; Supino, S; Forli, S; Rovini, M; Cappelli, A; Manetti, F; Botta, M; Sautebin, L; Rossi, A; Pergola, C; Ghelardini, C; Vivoli, E; Makovec, F; Anzellotti, P; Patrignani, P; Anzini, M Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. J Med Chem50:5403-11 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 1 |
|---|
| Name: | Prostaglandin G/H synthase 1 |
|---|
| Synonyms: | Cox-1 | Cox1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_MOUSE | PGHS-1 | PHS 1 | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 | Ptgs1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69044.61 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_10575 |
|---|
| Residue: | 602 |
|---|
| Sequence: | MSRRSLSLWFPLLLLLLLPPTPSVLLADPGVPSPVNPCCYYPCQNQGVCVRFGLDNYQCD
CTRTGYSGPNCTIPEIWTWLRNSLRPSPSFTHFLLTHGYWLWEFVNATFIREVLMRLVLT
VRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDVQLLA
QQLLLRREFIPAPQGTNILFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNL
ERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPERQMAVGQEVFGLLPGL
MLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIVIEEYVQHLSGYFLQ
LKFDPELLFRAQFQYRNRIAMEFNHLYHWHPLMPNSFQVGSQEYSYEQFLFNTSMLVDYG
VEALVDAFSRQRAGRIGGGRNFDYHVLHVAVDVIKESREMRLQPFNEYRKRFGLKPYTSF
QELTGEKEMAAELEELYGDIDALEFYPGLLLEKCQPNSIFGESMIEMGAPFSLKGLLGNP
ICSPEYWKPSTFGGDVGFNLVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVLVRRST
EL
|
|
|
|---|
| BDBM50224124 |
|---|
| n/a |
|---|
| Name | BDBM50224124 |
|---|
| Synonyms: | CHEMBL237813 | ethyl-2-methyl-1-[4-(methylsulfonyl)phenyl]-5-[4-(methoxy)phenyl]-1H-pyrrol-3-acetate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25NO5S |
|---|
| Mol. Mass. | 427.513 |
|---|
| SMILES | CCOC(=O)Cc1cc(-c2ccc(OC)cc2)n(c1C)-c1ccc(cc1)S(C)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
