Reaction Details |
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Target | Transthyretin |
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Ligand | BDBM50225227 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_451108 (CHEMBL900187) |
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pH | 4.4±n/a |
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IC50 | 3160±n/a nM |
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Comments | extracted |
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Citation | Gupta, S; Chhibber, M; Sinha, S; Surolia, A Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. J Med Chem50:5589-99 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transthyretin |
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Name: | Transthyretin |
Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
Type: | Enzyme |
Mol. Mass.: | 15884.31 |
Organism: | Homo sapiens (Human) |
Description: | P02766 |
Residue: | 147 |
Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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BDBM50225227 |
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n/a |
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Name | BDBM50225227 |
Synonyms: | 2,4-dichloro-1-(4-(chloromethyl)-2-methoxyphenoxy)benzene | CHEMBL240807 |
Type | Small organic molecule |
Emp. Form. | C14H11Cl3O2 |
Mol. Mass. | 317.595 |
SMILES | COc1cc(CCl)ccc1Oc1ccc(Cl)cc1Cl |
Structure |
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