| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50227744 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_452360 (CHEMBL902599) |
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| EC50 | 2654±n/a nM |
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| Citation |  Shi, Q; Canada, EJ; Xu, Y; Warshawsky, AM; Etgen, GJ; Broderick, CL; Clutinger, CK; Irwin, LA; Laurila, ME; Montrose-Rafizadeh, C; Oldham, BA; Wang, M; Winneroski, LL; Xie, C; York, JS; Yumibe, NP; Zink, RW; Mantlo, N Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists. Bioorg Med Chem Lett17:6744-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50227744 |
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| n/a |
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| Name | BDBM50227744 |
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| Synonyms: | 3-(4-(3-((5-chloro-1,3-dimethyl-1H-indole-2-carboxamido)methyl)phenoxy)-2-methylphenyl)propanoic acid | CHEMBL238152 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27ClN2O4 |
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| Mol. Mass. | 490.978 |
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| SMILES | Cc1c(C(=O)NCc2cccc(Oc3ccc(CCC(O)=O)c(C)c3)c2)n(C)c2ccc(Cl)cc12 |
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| Structure | 
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