Found 609 hits with Last Name = 'warshawsky' and Initial = 'am' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neprilysin
(Rattus norvegicus (Rat)) | BDBM50175518
((3R,7S)-7-((R)-2-Mercapto-3-phenyl-propionylamino)...)Show SMILES OC(=O)[C@H]1CCCC2N1C(=O)[C@H](Cc1ccccc21)NC(=O)[C@H](S)Cc1ccccc1 Show InChI InChI=1S/C24H26N2O4S/c27-22(21(31)13-15-7-2-1-3-8-15)25-18-14-16-9-4-5-10-17(16)19-11-6-12-20(24(29)30)26(19)23(18)28/h1-5,7-10,18-21,31H,6,11-14H2,(H,25,27)(H,29,30)/t18-,19?,20+,21+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition of neutral endopeptidase (NEP). |
Bioorg Med Chem Lett 6: 957-962 (1996)
Article DOI: 10.1016/0960-894X(96)00149-7
BindingDB Entry DOI: 10.7270/Q2BV7GMV |
More data for this
Ligand-Target Pair | |
Neprilysin
(Rattus norvegicus (Rat)) | BDBM50289194
((S)-2-[(S)-4-((R)-2-Mercapto-3-phenyl-propionylami...)Show SMILES CC(C)C[C@H](N1Cc2ccccc2C[C@H](NC(=O)[C@H](S)Cc2ccccc2)C1=O)C(O)=O Show InChI InChI=1S/C25H30N2O4S/c1-16(2)12-21(25(30)31)27-15-19-11-7-6-10-18(19)14-20(24(27)29)26-23(28)22(32)13-17-8-4-3-5-9-17/h3-11,16,20-22,32H,12-15H2,1-2H3,(H,26,28)(H,30,31)/t20-,21-,22+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition of neutral endopeptidase (NEP). |
Bioorg Med Chem Lett 6: 957-962 (1996)
Article DOI: 10.1016/0960-894X(96)00149-7
BindingDB Entry DOI: 10.7270/Q2BV7GMV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM154981
(US9000043, 1)Show SMILES CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C22H27NO5/c1-15(2)20(28-14-13-27-19-7-5-4-6-8-19)21(24)23-16(3)17-9-11-18(12-10-17)22(25)26/h4-12,15-16,20H,13-14H2,1-3H3,(H,23,24)(H,25,26)/t16-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Eli Lilly and Company
US Patent
| Assay Description
hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban... |
US Patent US9000043 (2015)
BindingDB Entry DOI: 10.7270/Q26T0KCQ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50140256
(CHEMBL3740223)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(cc2ccccc12)-c1cccc(CO)c1 Show InChI InChI=1S/C27H23NO4/c1-16-10-11-22(27(31)32)17(2)25(16)28-26(30)24-14-21(13-20-7-3-4-9-23(20)24)19-8-5-6-18(12-19)15-29/h3-14,29H,15H2,1-2H3,(H,28,30)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50140258
(CHEMBL3740325)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(cc2ccccc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C26H20ClNO3/c1-15-10-11-21(26(30)31)16(2)24(15)28-25(29)23-14-19(17-7-5-8-20(27)13-17)12-18-6-3-4-9-22(18)23/h3-14H,1-2H3,(H,28,29)(H,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50499955
(CHEMBL3741430)Show SMILES Cc1cc(cc(C)c1NC(=O)c1cc(cc2ccccc12)-c1cccc(CO)c1)C(O)=O Show InChI InChI=1S/C27H23NO4/c1-16-10-22(27(31)32)11-17(2)25(16)28-26(30)24-14-21(13-20-7-3-4-9-23(20)24)19-8-5-6-18(12-19)15-29/h3-14,29H,15H2,1-2H3,(H,28,30)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50200369
(CHEMBL3915620)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)cc2)cc1 |r,c:26| Show InChI InChI=1S/C33H33NO3/c1-2-5-29(22-32(35)36)27-12-14-30(15-13-27)37-24-26-10-8-25(9-11-26)23-34-20-18-33(19-21-34)17-16-28-6-3-4-7-31(28)33/h3-4,6-17,29H,18-24H2,1H3,(H,35,36)/t29-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50499950
(CHEMBL3739435)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(cc2ccccc12)-c1ccccc1 Show InChI InChI=1S/C26H21NO3/c1-16-12-13-21(26(29)30)17(2)24(16)27-25(28)23-15-20(18-8-4-3-5-9-18)14-19-10-6-7-11-22(19)23/h3-15H,1-2H3,(H,27,28)(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50499949
(CHEMBL3742015)Show SMILES Cc1cc(cc(C)c1NC(=O)c1cc(cc2ccccc12)-c1ccccc1)C(O)=O Show InChI InChI=1S/C26H21NO3/c1-16-12-21(26(29)30)13-17(2)24(16)27-25(28)23-15-20(18-8-4-3-5-9-18)14-19-10-6-7-11-22(19)23/h3-15H,1-2H3,(H,27,28)(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50247164
(CHEMBL4101901)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(s2)N2CCC3(CCc4ccccc34)CC2)cc1 |r| Show InChI InChI=1S/C30H31NO3S/c1-2-5-24(20-29(32)33)22-8-10-25(11-9-22)34-21-26-12-13-28(35-26)31-18-16-30(17-19-31)15-14-23-6-3-4-7-27(23)30/h3-4,6-13,24H,14-21H2,1H3,(H,32,33)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50204020
(CHEMBL3927519)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2c(C)cccc2C)cc1 |r| Show InChI InChI=1S/C27H25N3O3/c1-4-6-22(15-25(31)32)21-10-12-23(13-11-21)33-17-20-9-14-24-28-27(29-30(24)16-20)26-18(2)7-5-8-19(26)3/h5,7-14,16,22H,15,17H2,1-3H3,(H,31,32)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50499954
(CHEMBL3741902)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(nc2ccccc12)-c1cccc(CO)c1 Show InChI InChI=1S/C26H22N2O4/c1-15-10-11-19(26(31)32)16(2)24(15)28-25(30)21-13-23(18-7-5-6-17(12-18)14-29)27-22-9-4-3-8-20(21)22/h3-13,29H,14H2,1-2H3,(H,28,30)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50204012
(CHEMBL3955132)Show SMILES COc1cccc2CCCN(Cc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)s3)c12 |r| Show InChI InChI=1S/C28H29NO4S/c1-3-6-22(17-27(30)31)20-10-12-23(13-11-20)33-19-25-15-14-24(34-25)18-29-16-5-8-21-7-4-9-26(32-2)28(21)29/h4,7,9-15,22H,5,8,16-19H2,1-2H3,(H,30,31)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50247166
(CHEMBL4082711)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2ccc(cc2)C(C)C)cc1 |r| Show InChI InChI=1S/C28H27N3O3/c1-4-5-24(16-27(32)33)22-11-13-25(14-12-22)34-18-20-6-15-26-29-28(30-31(26)17-20)23-9-7-21(8-10-23)19(2)3/h6-15,17,19,24H,16,18H2,1-3H3,(H,32,33)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50247163
(CHEMBL4059614)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2ccc(cc2)C#N)cc1 |r| Show InChI InChI=1S/C26H20N4O3/c1-2-3-22(14-25(31)32)20-9-11-23(12-10-20)33-17-19-6-13-24-28-26(29-30(24)16-19)21-7-4-18(15-27)5-8-21/h4-13,16,22H,14,17H2,1H3,(H,31,32)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50247156
(CHEMBL4101472)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2ccc(OCCC(C)(C)O)cc2)cc1 |r| Show InChI InChI=1S/C30H31N3O5/c1-4-5-24(18-28(34)35)22-7-11-26(12-8-22)38-20-21-6-15-27-31-29(32-33(27)19-21)23-9-13-25(14-10-23)37-17-16-30(2,3)36/h6-15,19,24,36H,16-18,20H2,1-3H3,(H,34,35)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50499952
(CHEMBL3741642)Show SMILES Cc1cc(cc(C)c1NC(=O)c1cc(nc2ccccc12)-c1ccccc1)C(O)=O Show InChI InChI=1S/C25H20N2O3/c1-15-12-18(25(29)30)13-16(2)23(15)27-24(28)20-14-22(17-8-4-3-5-9-17)26-21-11-7-6-10-19(20)21/h3-14H,1-2H3,(H,27,28)(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50107278
(CHEMBL3600884)Show SMILES Cl.C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccc(F)cc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C23H27FN2O4/c1-16(17-5-7-18(8-6-17)23(28)29)25-22(27)21-4-2-3-13-26(21)14-15-30-20-11-9-19(24)10-12-20/h5-12,16,21H,2-4,13-15H2,1H3,(H,25,27)(H,28,29)/t16-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy... |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50446847
(CHEMBL3115074)Show SMILES C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C23H28N2O4/c1-17(18-10-12-19(13-11-18)23(27)28)24-22(26)21-9-5-6-14-25(21)15-16-29-20-7-3-2-4-8-20/h2-4,7-8,10-13,17,21H,5-6,9,14-16H2,1H3,(H,24,26)(H,27,28)/t17-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC sid
UniChem
| Article
PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy... |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50107280
(CHEMBL3600788)Show SMILES Cl.OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1CCCCN1CCOc1ccccc1 |r| Show InChI InChI=1S/C24H28N2O4/c27-22(25-24(13-14-24)19-11-9-18(10-12-19)23(28)29)21-8-4-5-15-26(21)16-17-30-20-6-2-1-3-7-20/h1-3,6-7,9-12,21H,4-5,8,13-17H2,(H,25,27)(H,28,29)/t21-/m1/s1 | PDB
Reactome pathway
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| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy... |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50499953
(CHEMBL3739779)Show SMILES Cc1cc(cc(C)c1NC(=O)c1cc(nc2ccccc12)-c1cccc(CO)c1)C(O)=O Show InChI InChI=1S/C26H22N2O4/c1-15-10-19(26(31)32)11-16(2)24(15)28-25(30)21-13-23(18-7-5-6-17(12-18)14-29)27-22-9-4-3-8-20(21)22/h3-13,29H,14H2,1-2H3,(H,28,30)(H,31,32) | PDB
Reactome pathway
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| Article
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| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM142234
(US8933098, 1 | US8933099, 1)Show SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)N1CCC(O)CC1 Show InChI InChI=1S/C21H25N3O4/c1-12-4-5-17(24-8-6-16(25)7-9-24)22-19(12)20(26)23-18-13(2)10-15(21(27)28)11-14(18)3/h4-5,10-11,16,25H,6-9H2,1-3H3,(H,23,26)(H,27,28) | PDB
Reactome pathway
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| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human EP4 |
Bioorg Med Chem Lett 26: 2303-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.041
BindingDB Entry DOI: 10.7270/Q22F7QBJ |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50247167
(CHEMBL4097527)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2ccc(OC(F)F)cc2)cc1 |r| Show InChI InChI=1S/C26H21F2N3O4/c1-2-3-20(14-24(32)33)18-5-9-21(10-6-18)34-16-17-4-13-23-29-25(30-31(23)15-17)19-7-11-22(12-8-19)35-26(27)28/h4-13,15,20,26H,14,16H2,1H3,(H,32,33)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
| Article
PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50247162
(CHEMBL4075819)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2c(C)cc(OCCCS(C)(=O)=O)cc2C)cc1 |r| Show InChI InChI=1S/C31H33N3O6S/c1-5-7-25(18-29(35)36)24-9-11-26(12-10-24)40-20-23-8-13-28-32-31(33-34(28)19-23)30-21(2)16-27(17-22(30)3)39-14-6-15-41(4,37)38/h8-13,16-17,19,25H,6,14-15,18,20H2,1-4H3,(H,35,36)/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
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UniChem
Similars
| Article
PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50247165
(CHEMBL4077366)Show SMILES COCCOc1ccc(cc1)-c1nc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cn2n1 |r| Show InChI InChI=1S/C28H27N3O5/c1-3-4-23(17-27(32)33)21-6-10-25(11-7-21)36-19-20-5-14-26-29-28(30-31(26)18-20)22-8-12-24(13-9-22)35-16-15-34-2/h5-14,18,23H,15-17,19H2,1-2H3,(H,32,33)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 102 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Competitive displacement of [3H]-TAK-875 from full length human recombinant GPR40 expressed in HEK293 cell membranes after 2 hrs by scintillation cou... |
J Med Chem 61: 934-945 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01411
BindingDB Entry DOI: 10.7270/Q2CZ39K5 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50107282
(CHEMBL3600786)Show SMILES Cl.OC(=O)c1ccc(CNC(=O)[C@H]2CCCCN2CCOc2ccccc2)cc1 |r| Show InChI InChI=1S/C22H26N2O4/c25-21(23-16-17-9-11-18(12-10-17)22(26)27)20-8-4-5-13-24(20)14-15-28-19-6-2-1-3-7-19/h1-3,6-7,9-12,20H,4-5,8,13-16H2,(H,23,25)(H,26,27)/t20-/m1/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
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| Article
PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy... |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50107281
(CHEMBL3600787)Show SMILES Cl.CC[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H30N2O4/c1-2-21(18-11-13-19(14-12-18)24(28)29)25-23(27)22-10-6-7-15-26(22)16-17-30-20-8-4-3-5-9-20/h3-5,8-9,11-14,21-22H,2,6-7,10,15-17H2,1H3,(H,25,27)(H,28,29)/t21-,22+/m0/s1 | PDB
Reactome pathway
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PubMed
| 129 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy... |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM154981
(US9000043, 1)Show SMILES CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C22H27NO5/c1-15(2)20(28-14-13-27-19-7-5-4-6-8-19)21(24)23-16(3)17-9-11-18(12-10-17)22(25)26/h4-12,15-16,20H,13-14H2,1-3H3,(H,23,24)(H,25,26)/t16-,20+/m0/s1 | PDB
Reactome pathway
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| US Patent
| 261 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Eli Lilly and Company
US Patent
| Assay Description
hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban... |
US Patent US9000043 (2015)
BindingDB Entry DOI: 10.7270/Q26T0KCQ |
More data for this
Ligand-Target Pair | |
Neprilysin
(Rattus norvegicus (Rat)) | BDBM50281462
((R)-2-[(6S,7S)-6-((R)-2-Mercapto-3-phenyl-propiony...)Show SMILES CC(C)C[C@@H](N1CCO[C@H]([C@H](NC(=O)[C@H](S)Cc2ccccc2)C1=O)c1ccccc1)C(O)=O Show InChI InChI=1S/C26H32N2O5S/c1-17(2)15-20(26(31)32)28-13-14-33-23(19-11-7-4-8-12-19)22(25(28)30)27-24(29)21(34)16-18-9-5-3-6-10-18/h3-12,17,20-23,34H,13-16H2,1-2H3,(H,27,29)(H,31,32)/t20-,21-,22+,23+/m1/s1 | PDB
MMDB
Reactome pathway
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B.MOAD
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| Article
| 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition of neutral endopeptidase (NEP). |
Bioorg Med Chem Lett 6: 957-962 (1996)
Article DOI: 10.1016/0960-894X(96)00149-7
BindingDB Entry DOI: 10.7270/Q2BV7GMV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50107279
(CHEMBL3600883)Show SMILES Cl.C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccc(cc1)C#N)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H27N3O4/c1-17(19-7-9-20(10-8-19)24(29)30)26-23(28)22-4-2-3-13-27(22)14-15-31-21-11-5-18(16-25)6-12-21/h5-12,17,22H,2-4,13-15H2,1H3,(H,26,28)(H,29,30)/t17-,22+/m0/s1 | PDB
Reactome pathway
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PC sid
UniChem
Similars
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PubMed
| 372 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy... |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50107283
(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)Show SMILES CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C26H29N5O3S/c1-5-24-29-25-19(4)28-18(3)16-23(25)31(24)21-10-8-20(9-11-21)14-15-27-26(32)30-35(33,34)22-12-6-17(2)7-13-22/h6-13,16H,5,14-15H2,1-4H3,(H2,27,30,32) | PDB
Reactome pathway
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UniChem
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| Article
PubMed
| 448 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50107283
(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)Show SMILES CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C26H29N5O3S/c1-5-24-29-25-19(4)28-18(3)16-23(25)31(24)21-10-8-20(9-11-21)14-15-27-26(32)30-35(33,34)22-12-6-17(2)7-13-22/h6-13,16H,5,14-15H2,1-4H3,(H2,27,30,32) | PDB
Reactome pathway
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UniChem
Similars
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PubMed
| 449 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy... |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50499956
(CHEMBL3741710)Show SMILES Cc1cccc(C)c1NC(=O)c1cc(nc2ccccc12)-c1ccccc1 Show InChI InChI=1S/C24H20N2O/c1-16-9-8-10-17(2)23(16)26-24(27)20-15-22(18-11-4-3-5-12-18)25-21-14-7-6-13-19(20)21/h3-15H,1-2H3,(H,26,27) | PDB
Reactome pathway
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| Article
PubMed
| 512 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50446847
(CHEMBL3115074)Show SMILES C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C23H28N2O4/c1-17(18-10-12-19(13-11-18)23(27)28)24-22(26)21-9-5-6-14-25(21)15-16-29-20-7-3-2-4-8-20/h2-4,7-8,10-13,17,21H,5-6,9,14-16H2,1H3,(H,24,26)(H,27,28)/t17-,21+/m0/s1 | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 1.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50140258
(CHEMBL3740325)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(cc2ccccc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C26H20ClNO3/c1-15-10-11-21(26(30)31)16(2)24(15)28-25(29)23-14-19(17-7-5-8-20(27)13-17)12-18-6-3-4-9-22(18)23/h3-14H,1-2H3,(H,28,29)(H,30,31) | PDB
Reactome pathway
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Similars
| Article
PubMed
| 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP2 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50446847
(CHEMBL3115074)Show SMILES C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C23H28N2O4/c1-17(18-10-12-19(13-11-18)23(27)28)24-22(26)21-9-5-6-14-25(21)15-16-29-20-7-3-2-4-8-20/h2-4,7-8,10-13,17,21H,5-6,9,14-16H2,1H3,(H,24,26)(H,27,28)/t17-,21+/m0/s1 | PDB
KEGG
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PC cid
PC sid
UniChem
| Article
PubMed
| >1.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP3 receptor by liquid scintillation counting analysis |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM154981
(US9000043, 1)Show SMILES CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C22H27NO5/c1-15(2)20(28-14-13-27-19-7-5-4-6-8-19)21(24)23-16(3)17-9-11-18(12-10-17)22(25)26/h4-12,15-16,20H,13-14H2,1-3H3,(H,23,24)(H,25,26)/t16-,20+/m0/s1 | PDB
KEGG
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| US Patent
| >1.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Eli Lilly and Company
US Patent
| Assay Description
hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban... |
US Patent US9000043 (2015)
BindingDB Entry DOI: 10.7270/Q26T0KCQ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM142234
(US8933098, 1 | US8933099, 1)Show SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)N1CCC(O)CC1 Show InChI InChI=1S/C21H25N3O4/c1-12-4-5-17(24-8-6-16(25)7-9-24)22-19(12)20(26)23-18-13(2)10-15(21(27)28)11-14(18)3/h4-5,10-11,16,25H,6-9H2,1-3H3,(H,23,26)(H,27,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human EP3 |
Bioorg Med Chem Lett 26: 2303-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.041
BindingDB Entry DOI: 10.7270/Q22F7QBJ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50140255
(CHEMBL3754085)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1nc(ccc1C)-c1cccc(CO)c1 Show InChI InChI=1S/C23H22N2O4/c1-13-7-9-18(23(28)29)15(3)20(13)25-22(27)21-14(2)8-10-19(24-21)17-6-4-5-16(11-17)12-26/h4-11,26H,12H2,1-3H3,(H,25,27)(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human EP3 receptor |
Bioorg Med Chem Lett 26: 931-5 (2016)
Article DOI: 10.1016/j.bmcl.2015.12.057
BindingDB Entry DOI: 10.7270/Q22F7Q93 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM154981
(US9000043, 1)Show SMILES CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C22H27NO5/c1-15(2)20(28-14-13-27-19-7-5-4-6-8-19)21(24)23-16(3)17-9-11-18(12-10-17)22(25)26/h4-12,15-16,20H,13-14H2,1-3H3,(H,23,24)(H,25,26)/t16-,20+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| >1.74E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Eli Lilly and Company
US Patent
| Assay Description
hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban... |
US Patent US9000043 (2015)
BindingDB Entry DOI: 10.7270/Q26T0KCQ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM142234
(US8933098, 1 | US8933099, 1)Show SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)N1CCC(O)CC1 Show InChI InChI=1S/C21H25N3O4/c1-12-4-5-17(24-8-6-16(25)7-9-24)22-19(12)20(26)23-18-13(2)10-15(21(27)28)11-14(18)3/h4-5,10-11,16,25H,6-9H2,1-3H3,(H,23,26)(H,27,28) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human EP1 |
Bioorg Med Chem Lett 26: 2303-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.041
BindingDB Entry DOI: 10.7270/Q22F7QBJ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50140258
(CHEMBL3740325)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(cc2ccccc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C26H20ClNO3/c1-15-10-11-21(26(30)31)16(2)24(15)28-25(29)23-14-19(17-7-5-8-20(27)13-17)12-18-6-3-4-9-22(18)23/h3-14H,1-2H3,(H,28,29)(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50140255
(CHEMBL3754085)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1nc(ccc1C)-c1cccc(CO)c1 Show InChI InChI=1S/C23H22N2O4/c1-13-7-9-18(23(28)29)15(3)20(13)25-22(27)21-14(2)8-10-19(24-21)17-6-4-5-16(11-17)12-26/h4-11,26H,12H2,1-3H3,(H,25,27)(H,28,29) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human EP1 receptor |
Bioorg Med Chem Lett 26: 931-5 (2016)
Article DOI: 10.1016/j.bmcl.2015.12.057
BindingDB Entry DOI: 10.7270/Q22F7Q93 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50446847
(CHEMBL3115074)Show SMILES C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C23H28N2O4/c1-17(18-10-12-19(13-11-18)23(27)28)24-22(26)21-9-5-6-14-25(21)15-16-29-20-7-3-2-4-8-20/h2-4,7-8,10-13,17,21H,5-6,9,14-16H2,1H3,(H,24,26)(H,27,28)/t17-,21+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >1.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP1 receptor by liquid scintillation counting analysis |
Bioorg Med Chem Lett 25: 3176-8 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.091
BindingDB Entry DOI: 10.7270/Q2FX7C79 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50140255
(CHEMBL3754085)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1nc(ccc1C)-c1cccc(CO)c1 Show InChI InChI=1S/C23H22N2O4/c1-13-7-9-18(23(28)29)15(3)20(13)25-22(27)21-14(2)8-10-19(24-21)17-6-4-5-16(11-17)12-26/h4-11,26H,12H2,1-3H3,(H,25,27)(H,28,29) | PDB
Reactome pathway
KEGG
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human EP2 receptor |
Bioorg Med Chem Lett 26: 931-5 (2016)
Article DOI: 10.1016/j.bmcl.2015.12.057
BindingDB Entry DOI: 10.7270/Q22F7Q93 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM142234
(US8933098, 1 | US8933099, 1)Show SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)N1CCC(O)CC1 Show InChI InChI=1S/C21H25N3O4/c1-12-4-5-17(24-8-6-16(25)7-9-24)22-19(12)20(26)23-18-13(2)10-15(21(27)28)11-14(18)3/h4-5,10-11,16,25H,6-9H2,1-3H3,(H,23,26)(H,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human EP2 |
Bioorg Med Chem Lett 26: 2303-7 (2016)
Article DOI: 10.1016/j.bmcl.2016.03.041
BindingDB Entry DOI: 10.7270/Q22F7QBJ |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50499951
(CHEMBL3739886)Show SMILES Cc1cccc(C)c1NC(=O)c1cc(nc2ccccc12)-c1ccc(cc1)C(O)=O Show InChI InChI=1S/C25H20N2O3/c1-15-6-5-7-16(2)23(15)27-24(28)20-14-22(26-21-9-4-3-8-19(20)21)17-10-12-18(13-11-17)25(29)30/h3-14H,1-2H3,(H,27,28)(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.92E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50140258
(CHEMBL3740325)Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(cc2ccccc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C26H20ClNO3/c1-15-10-11-21(26(30)31)16(2)24(15)28-25(29)23-14-19(17-7-5-8-20(27)13-17)12-18-6-3-4-9-22(18)23/h3-14H,1-2H3,(H,28,29)(H,30,31) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP1 receptor |
Bioorg Med Chem Lett 26: 105-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.023
BindingDB Entry DOI: 10.7270/Q2G73HRK |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50140261
(CHEMBL3753860)Show SMILES Cc1ccc(cc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)-c1cccc(CO)c1 Show InChI InChI=1S/C24H23NO4/c1-14-7-8-19(18-6-4-5-17(11-18)13-26)12-21(14)23(27)25-22-15(2)9-20(24(28)29)10-16(22)3/h4-12,26H,13H2,1-3H3,(H,25,27)(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa... |
Bioorg Med Chem Lett 26: 931-5 (2016)
Article DOI: 10.1016/j.bmcl.2015.12.057
BindingDB Entry DOI: 10.7270/Q22F7Q93 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50140253
(CHEMBL3752948)Show SMILES Cc1cc(cc(C)c1NC(=O)c1nc(ccc1C(F)(F)F)-c1cccc(CO)c1)C(O)=O Show InChI InChI=1S/C23H19F3N2O4/c1-12-8-16(22(31)32)9-13(2)19(12)28-21(30)20-17(23(24,25)26)6-7-18(27-20)15-5-3-4-14(10-15)11-29/h3-10,29H,11H2,1-2H3,(H,28,30)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa... |
Bioorg Med Chem Lett 26: 931-5 (2016)
Article DOI: 10.1016/j.bmcl.2015.12.057
BindingDB Entry DOI: 10.7270/Q22F7Q93 |
More data for this
Ligand-Target Pair | |
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