Ki Summary

Reaction Details

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Target

Neprilysin

Ligand

BDBM50281462

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_144622

330±n/a nM

Citation

Warshawsky, AM; Flynn, GA; Koehl, JR; Mehdi, S; Vaz, RJ The synthesis of aminobenzazepinones as anti-phenylalanine dipeptide mimics and their use in nep inhibition Bioorg Med Chem Lett6:957-962 (1996) Article

More Info.:

Get all data from this article, Assay Method

Neprilysin

Name:

Neprilysin

Synonyms:

Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11

Type:

Protein

Mol. Mass.:

85789.59

Organism:

Rattus norvegicus (Rat)

Description:

P07861

Residue:

750

Sequence:

MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW

BDBM50281462

n/a

Name

BDBM50281462

Synonyms:

(R)-2-[(6S,7S)-6-((R)-2-Mercapto-3-phenyl-propionylamino)-5-oxo-7-phenyl-[1,4]oxazepan-4-yl]-4-methyl-pentanoic acid | (S)-2-[(6S,7S)-6-((R)-2-Mercapto-3-phenyl-propionylamino)-5-oxo-7-phenyl-[1,4]oxazepan-4-yl]-4-methyl-pentanoic acid | CHEMBL311838 | MDL-100192

Type

Small organic molecule

Emp. Form.

C26H32N2O5S

Mol. Mass.

484.608

SMILES

CC(C)C[C@@H](N1CCO[C@H]([C@H](NC(=O)[C@H](S)Cc2ccccc2)C1=O)c1ccccc1)C(O)=O

Structure