| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
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| Ligand | BDBM50499953 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1541019 (CHEMBL3744250) |
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| Ki | 52±n/a nM |
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| Citation |  Blanco, MJ; Vetman, T; Chandrasekhar, S; Fisher, MJ; Harvey, A; Mudra, D; Wang, XS; Yu, XP; Schiffler, MA; Warshawsky, AM Discovery of substituted-2,4-dimethyl-(naphthalene-4-carbonyl)amino-benzoic acid as potent and selective EP4 antagonists. Bioorg Med Chem Lett26:105-9 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP4 subtype |
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| Name: | Prostaglandin E2 receptor EP4 subtype |
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| Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 53134.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35408 |
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| Residue: | 488 |
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| Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
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| BDBM50499953 |
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| n/a |
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| Name | BDBM50499953 |
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| Synonyms: | CHEMBL3739779 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22N2O4 |
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| Mol. Mass. | 426.4639 |
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| SMILES | Cc1cc(cc(C)c1NC(=O)c1cc(nc2ccccc12)-c1cccc(CO)c1)C(O)=O |
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| Structure | 
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