| Reaction Details |
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 | Report a problem with these data |
| Target | D(3) dopamine receptor |
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| Ligand | BDBM50229781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_460309 (CHEMBL926380) |
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| Ki | 22.2±n/a nM |
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| Citation |  Biswas, S; Zhang, S; Fernandez, F; Ghosh, B; Zhen, J; Kuzhikandathil, E; Reith, ME; Dutta, AK Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action. J Med Chem51:101-17 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(3) dopamine receptor |
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| Name: | D(3) dopamine receptor |
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| Synonyms: | DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3 |
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| Type: | n/a |
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| Mol. Mass.: | 44243.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 400 |
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| Sequence: | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
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| BDBM50229781 |
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| n/a |
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| Name | BDBM50229781 |
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| Synonyms: | CHEMBL252342 | N2-[2-(4-phenylpiperazin-1-yl)ethyl]-N2-propyl-1,2,3,4-tetrahydronaphthalene-2,7-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C25H36N4 |
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| Mol. Mass. | 392.5801 |
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| SMILES | CCCN(CCN1CCN(CC1)c1ccccc1)C1CCc2ccc(N)cc2C1 |w:18.19| |
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| Structure | 
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