| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50231619 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_462015 (CHEMBL944858) |
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| IC50 | 6±n/a nM |
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| Citation |  Pasternak, A; Goble, SD; Vicario, PP; Di Salvo, J; Ayala, JM; Struthers, M; DeMartino, JA; Mills, SG; Yang, L Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists. Bioorg Med Chem Lett18:994-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50231619 |
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| n/a |
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| Name | BDBM50231619 |
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| Synonyms: | (1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-(2-hydroxypropan-2-yl)-3-(4-(pyrimidin-5-yl)piperidin-1-yl)cyclopentanecarboxamide | CHEMBL429849 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32F6N4O2 |
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| Mol. Mass. | 558.559 |
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| SMILES | CC(C)(O)[C@@]1(CC[C@H](C1)N1CCC(CC1)c1cncnc1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |
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| Structure | 
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