| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
|---|
| Ligand | BDBM50251024 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_529877 (CHEMBL968427) |
|---|
| IC50 | 44400±n/a nM |
|---|
| Citation |  Alexiou, P; Nicolaou, I; Stefek, M; Kristl, A; Demopoulos, VJ Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors. Bioorg Med Chem16:3926-32 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member B1 |
|---|
| Name: | Aldo-keto reductase family 1 member B1 |
|---|
| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35797.87 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1512484 |
|---|
| Residue: | 316 |
|---|
| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
|
|
|
|---|
| BDBM50251024 |
|---|
| n/a |
|---|
| Name | BDBM50251024 |
|---|
| Synonyms: | CHEMBL457486 | N-(3,5-Difluoro-4-hydroxyphenyl)-4-nitrobenzenesulfonamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H8F2N2O5S |
|---|
| Mol. Mass. | 330.264 |
|---|
| SMILES | Oc1c(F)cc(NS(=O)(=O)c2ccc(cc2)[N+]([O-])=O)cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
