| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50260340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_530043 (CHEMBL978693) |
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| IC50 | 1320±n/a nM |
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| Citation |  Lefoix, M; Coudert, G; Routier, S; Pfeiffer, B; Caignard, DH; Hickman, J; Pierré, A; Golsteyn, RM; Léonce, S; Bossard, C; Mérour, JY Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors. Bioorg Med Chem16:5303-21 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM50260340 |
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| n/a |
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| Name | BDBM50260340 |
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| Synonyms: | 9-Benzyloxy-1H-pyrido[3'4':4,5]pyrrolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione | CHEMBL523179 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H16N4O3 |
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| Mol. Mass. | 432.4302 |
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| SMILES | O=C1NC(=O)c2c1c1c3cnccc3[nH]c1c1[nH]c3ccc(OCc4ccccc4)cc3c21 |
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| Structure | 
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