Compile Data Set for Download or QSAR

Found 306 hits with Last Name = 'hickman' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50452012 (CHEMBL2110187) Show SMILES Clc1cccc(c1)N1Cc2ccccc2C[C@H](NCc2cncn2Cc2ccc(cc2)C#N)C1=O |r| Show InChI InChI=1S/C28H24ClN5O/c29-24-6-3-7-25(13-24)34-18-23-5-2-1-4-22(23)12-27(28(34)35)32-16-26-15-31-19-33(26)17-21-10-8-20(14-30)9-11-21/h1-11,13,15,19,27,32H,12,16-18H2/t27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50092365 ((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...) Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1cccs1 Show InChI InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177831 (US9120791, Example 50 | US9120791, Example 94 | US...) Show SMILES Cn1ncc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H44N6O6/c1-47-39-14-11-33(21-31(39)25-46-47)51(32-9-12-35(52)13-10-32)45(54)38-22-41(49-15-5-4-8-40(38)49)36-23-42-43(57-28-56-42)24-37(36)44(53)50-26-30-7-3-2-6-29(30)20-34(50)27-48-16-18-55-19-17-48/h2-3,6-7,9-14,21-25,34,52H,4-5,8,15-20,26-28H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139576 (4-(5-{[2-(2-Methyl-benzyl)-3-oxo-2,3,4,5-tetrahydr...) Show SMILES Cc1ccccc1CN1Cc2ccccc2CC(NCc2cncn2Cc2ccc(cc2)C#N)C1=O Show InChI InChI=1S/C30H29N5O/c1-22-6-2-3-8-26(22)19-34-20-27-9-5-4-7-25(27)14-29(30(34)36)33-17-28-16-32-21-35(28)18-24-12-10-23(15-31)11-13-24/h2-13,16,21,29,33H,14,17-20H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177831 (US9120791, Example 50 | US9120791, Example 94 | US...) Show SMILES Cn1ncc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H44N6O6/c1-47-39-14-11-33(21-31(39)25-46-47)51(32-9-12-35(52)13-10-32)45(54)38-22-41(49-15-5-4-8-40(38)49)36-23-42-43(57-28-56-42)24-37(36)44(53)50-26-30-7-3-2-6-29(30)20-34(50)27-48-16-18-55-19-17-48/h2-3,6-7,9-14,21-25,34,52H,4-5,8,15-20,26-28H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139567 (4-(5-{[2-(3-Chloro-phenyl)-3-oxo-2,3,4,5-tetrahydr...) Show SMILES Clc1cccc(c1)N1Cc2ccccc2CC(NCc2cncn2Cc2ccc(cc2)C#N)C1=O Show InChI InChI=1S/C28H24ClN5O/c29-24-6-3-7-25(13-24)34-18-23-5-2-1-4-22(23)12-27(28(34)35)32-16-26-15-31-19-33(26)17-21-10-8-20(14-30)9-11-21/h1-11,13,15,19,27,32H,12,16-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177867 (US9120791, Example 92 | US9603854, 92) Show SMILES Cc1ccc(cc1F)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H41FN4O7/c1-27-6-7-31(19-37(27)44)48(30-8-10-33(49)11-9-30)43(51)36-20-38(46-14-17-53-25-39(36)46)34-21-40-41(55-26-54-40)22-35(34)42(50)47-23-29-5-3-2-4-28(29)18-32(47)24-45-12-15-52-16-13-45/h2-11,19-22,32,49H,12-18,23-26H2,1H3/t32-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177875 (US9120791, Example 101 | US9603854, 101) Show SMILES Cn1ncc2cc(ccc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H41ClN6O5/c1-46-39-13-9-33(21-30(39)24-45-46)50(32-7-10-35(51)11-8-32)43(53)38-23-40(48-16-19-55-27-41(38)48)37-22-31(44)6-12-36(37)42(52)49-25-29-5-3-2-4-28(29)20-34(49)26-47-14-17-54-18-15-47/h2-13,21-24,34,51H,14-20,25-27H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177867 (US9120791, Example 92 | US9603854, 92) Show SMILES Cc1ccc(cc1F)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H41FN4O7/c1-27-6-7-31(19-37(27)44)48(30-8-10-33(49)11-9-30)43(51)36-20-38(46-14-17-53-25-39(36)46)34-21-40-41(55-26-54-40)22-35(34)42(50)47-23-29-5-3-2-4-28(29)18-32(47)24-45-12-15-52-16-13-45/h2-11,19-22,32,49H,12-18,23-26H2,1H3/t32-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177875 (US9120791, Example 101 | US9603854, 101) Show SMILES Cn1ncc2cc(ccc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H41ClN6O5/c1-46-39-13-9-33(21-30(39)24-45-46)50(32-7-10-35(51)11-8-32)43(53)38-23-40(48-16-19-55-27-41(38)48)37-22-31(44)6-12-36(37)42(52)49-25-29-5-3-2-4-28(29)20-34(49)26-47-14-17-54-18-15-47/h2-13,21-24,34,51H,14-20,25-27H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177869 (US9120791, Example 95 | US9603854, 95) Show SMILES Cc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)c2CCCCn12 Show InChI InChI=1S/C46H47N5O4/c1-31-10-16-39(45(53)50-29-34-8-4-3-7-32(34)26-37(50)30-48-21-23-55-24-22-48)40(25-31)44-28-41(43-9-5-6-19-49(43)44)46(54)51(35-11-14-38(52)15-12-35)36-13-17-42-33(27-36)18-20-47(42)2/h3-4,7-8,10-18,20,25,27-28,37,52H,5-6,9,19,21-24,26,29-30H2,1-2H3/t37-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177876 (US9120791, Example 103 | US9603854, 103) Show SMILES Cn1ccc2cc(cnc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C44H43ClN6O4/c1-47-17-15-30-23-34(26-46-42(30)47)51(33-10-12-36(52)13-11-33)44(54)39-25-41(49-16-5-4-8-40(39)49)38-24-32(45)9-14-37(38)43(53)50-27-31-7-3-2-6-29(31)22-35(50)28-48-18-20-55-21-19-48/h2-3,6-7,9-15,17,23-26,35,52H,4-5,8,16,18-22,27-28H2,1H3/t35-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177902 (US9120791, Example 135 | US9603854, 135) Show SMILES Cn1cc(cn1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C40H41ClN6O4/c1-43-25-32(23-42-43)47(30-10-12-33(48)13-11-30)40(50)36-22-38(45-15-5-4-8-37(36)45)35-21-29(41)9-14-34(35)39(49)46-24-28-7-3-2-6-27(28)20-31(46)26-44-16-18-51-19-17-44/h2-3,6-7,9-14,21-23,25,31,48H,4-5,8,15-20,24,26H2,1H3/t31-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139580 (4-(5-{[2-(3-Chloro-benzyl)-3-oxo-2,3,4,5-tetrahydr...) Show SMILES Clc1cccc(CN2Cc3ccccc3CC(NCc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 Show InChI InChI=1S/C29H26ClN5O/c30-26-7-3-4-23(12-26)18-34-19-25-6-2-1-5-24(25)13-28(29(34)36)33-16-27-15-32-20-35(27)17-22-10-8-21(14-31)9-11-22/h1-12,15,20,28,33H,13,16-19H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139588 (4-(5-{[2-(3-Methoxy-phenyl)-3-oxo-2,3,4,5-tetrahyd...) Show SMILES COc1cccc(c1)N1Cc2ccccc2CC(NCc2cncn2Cc2ccc(cc2)C#N)C1=O Show InChI InChI=1S/C29H27N5O2/c1-36-27-8-4-7-25(14-27)34-19-24-6-3-2-5-23(24)13-28(29(34)35)32-17-26-16-31-20-33(26)18-22-11-9-21(15-30)10-12-22/h2-12,14,16,20,28,32H,13,17-19H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177869 (US9120791, Example 95 | US9603854, 95) Show SMILES Cc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)c2CCCCn12 Show InChI InChI=1S/C46H47N5O4/c1-31-10-16-39(45(53)50-29-34-8-4-3-7-32(34)26-37(50)30-48-21-23-55-24-22-48)40(25-31)44-28-41(43-9-5-6-19-49(43)44)46(54)51(35-11-14-38(52)15-12-35)36-13-17-42-33(27-36)18-20-47(42)2/h3-4,7-8,10-18,20,25,27-28,37,52H,5-6,9,19,21-24,26,29-30H2,1-2H3/t37-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177876 (US9120791, Example 103 | US9603854, 103) Show SMILES Cn1ccc2cc(cnc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C44H43ClN6O4/c1-47-17-15-30-23-34(26-46-42(30)47)51(33-10-12-36(52)13-11-33)44(54)39-25-41(49-16-5-4-8-40(39)49)38-24-32(45)9-14-37(38)43(53)50-27-31-7-3-2-6-29(31)22-35(50)28-48-18-20-55-21-19-48/h2-3,6-7,9-15,17,23-26,35,52H,4-5,8,16,18-22,27-28H2,1H3/t35-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177902 (US9120791, Example 135 | US9603854, 135) Show SMILES Cn1cc(cn1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C40H41ClN6O4/c1-43-25-32(23-42-43)47(30-10-12-33(48)13-11-30)40(50)36-22-38(45-15-5-4-8-37(36)45)35-21-29(41)9-14-34(35)39(49)46-24-28-7-3-2-6-27(28)20-31(46)26-44-16-18-51-19-17-44/h2-3,6-7,9-14,21-23,25,31,48H,4-5,8,15-20,24,26H2,1H3/t31-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177877 (US9120791, Example 104 | US9603854, 104) Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ncc3c2)c2CCCCn12 Show InChI InChI=1S/C45H46N6O5/c1-47-41-17-12-34(24-32(41)27-46-47)51(33-10-13-36(52)14-11-33)45(54)40-26-43(49-18-6-5-9-42(40)49)39-25-37(55-2)15-16-38(39)44(53)50-28-31-8-4-3-7-30(31)23-35(50)29-48-19-21-56-22-20-48/h3-4,7-8,10-17,24-27,35,52H,5-6,9,18-23,28-29H2,1-2H3/t35-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177879 (US9120791, Example 107 | US9603854, 107) Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-c2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3CCCCn23)CC1=O Show InChI InChI=1S/C46H45ClN6O4/c1-48-20-18-31-24-35(13-17-41(31)48)53(34-11-14-37(54)15-12-34)46(57)40-26-43(51-19-6-5-9-42(40)51)39-25-33(47)10-16-38(39)45(56)52-27-32-8-4-3-7-30(32)23-36(52)28-50-22-21-49(2)44(55)29-50/h3-4,7-8,10-18,20,24-26,36,54H,5-6,9,19,21-23,27-29H2,1-2H3/t36-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177877 (US9120791, Example 104 | US9603854, 104) Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ncc3c2)c2CCCCn12 Show InChI InChI=1S/C45H46N6O5/c1-47-41-17-12-34(24-32(41)27-46-47)51(33-10-13-36(52)14-11-33)45(54)40-26-43(49-18-6-5-9-42(40)49)39-25-37(55-2)15-16-38(39)44(53)50-28-31-8-4-3-7-30(31)23-35(50)29-48-19-21-56-22-20-48/h3-4,7-8,10-17,24-27,35,52H,5-6,9,18-23,28-29H2,1-2H3/t35-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177879 (US9120791, Example 107 | US9603854, 107) Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Cl)cc2-c2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3CCCCn23)CC1=O Show InChI InChI=1S/C46H45ClN6O4/c1-48-20-18-31-24-35(13-17-41(31)48)53(34-11-14-37(54)15-12-34)46(57)40-26-43(51-19-6-5-9-42(40)51)39-25-33(47)10-16-38(39)45(56)52-27-32-8-4-3-7-30(32)23-36(52)28-50-22-21-49(2)44(55)29-50/h3-4,7-8,10-18,20,24-26,36,54H,5-6,9,19,21-23,27-29H2,1-2H3/t36-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177866 (US9120791, Example 91 | US9603854, 91) Show SMILES Cc1ccc(cc1F)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H42F2N4O4/c1-28-9-11-33(24-39(28)45)49(32-12-14-35(50)15-13-32)43(52)38-25-41(47-17-5-4-8-40(38)47)37-23-31(44)10-16-36(37)42(51)48-26-30-7-3-2-6-29(30)22-34(48)27-46-18-20-53-21-19-46/h2-3,6-7,9-16,23-25,34,50H,4-5,8,17-22,26-27H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177886 (US9120791, Example 115 | US9603854, 115) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccccc1F Show InChI InChI=1S/C42H40ClFN4O4/c43-30-12-17-34(41(50)47-26-29-8-2-1-7-28(29)23-32(47)27-45-19-21-52-22-20-45)35(24-30)40-25-36(38-10-5-6-18-46(38)40)42(51)48(31-13-15-33(49)16-14-31)39-11-4-3-9-37(39)44/h1-4,7-9,11-17,24-25,32,49H,5-6,10,18-23,26-27H2/t32-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139568 (4-{5-[((S)-1-Benzyl-2-oxo-azepan-3-ylamino)-methyl...) Show SMILES O=C1[C@H](CCCCN1Cc1ccccc1)NCc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C25H27N5O/c26-14-20-9-11-22(12-10-20)18-30-19-27-15-23(30)16-28-24-8-4-5-13-29(25(24)31)17-21-6-2-1-3-7-21/h1-3,6-7,9-12,15,19,24,28H,4-5,8,13,16-18H2/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139570 (4-(5-{[2-(3,5-Difluoro-benzyl)-3-oxo-2,3,4,5-tetra...) Show SMILES Fc1cc(F)cc(CN2Cc3ccccc3CC(NCc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 Show InChI InChI=1S/C29H25F2N5O/c30-25-9-22(10-26(31)12-25)17-35-18-24-4-2-1-3-23(24)11-28(29(35)37)34-15-27-14-33-19-36(27)16-21-7-5-20(13-32)6-8-21/h1-10,12,14,19,28,34H,11,15-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177866 (US9120791, Example 91 | US9603854, 91) Show SMILES Cc1ccc(cc1F)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H42F2N4O4/c1-28-9-11-33(24-39(28)45)49(32-12-14-35(50)15-13-32)43(52)38-25-41(47-17-5-4-8-40(38)47)37-23-31(44)10-16-36(37)42(51)48-26-30-7-3-2-6-29(30)22-34(48)27-46-18-20-53-21-19-46/h2-3,6-7,9-16,23-25,34,50H,4-5,8,17-22,26-27H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177886 (US9120791, Example 115 | US9603854, 115) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccccc1F Show InChI InChI=1S/C42H40ClFN4O4/c43-30-12-17-34(41(50)47-26-29-8-2-1-7-28(29)23-32(47)27-45-19-21-52-22-20-45)35(24-30)40-25-36(38-10-5-6-18-46(38)40)42(51)48(31-13-15-33(49)16-14-31)39-11-4-3-9-37(39)44/h1-4,7-9,11-17,24-25,32,49H,5-6,10,18-23,26-27H2/t32-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177880 (US9120791, Example 108 | US9603854, 108) Show SMILES COCCN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)c2CCCCn12 Show InChI InChI=1S/C45H46ClN5O4/c1-47(22-23-55-3)29-36-24-30-8-4-5-9-32(30)28-50(36)44(53)38-17-11-33(46)26-39(38)43-27-40(42-10-6-7-20-49(42)43)45(54)51(34-12-15-37(52)16-13-34)35-14-18-41-31(25-35)19-21-48(41)2/h4-5,8-9,11-19,21,25-27,36,52H,6-7,10,20,22-24,28-29H2,1-3H3/t36-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177883 (US9120791, Example 112 | US9603854, 112) Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2CCCCn12 Show InChI InChI=1S/C43H44N4O5/c1-51-36-18-19-37(42(49)46-28-31-10-6-5-9-30(31)25-34(46)29-44-21-23-52-24-22-44)38(26-36)41-27-39(40-13-7-8-20-45(40)41)43(50)47(32-11-3-2-4-12-32)33-14-16-35(48)17-15-33/h2-6,9-12,14-19,26-27,34,48H,7-8,13,20-25,28-29H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177885 (US9120791, Example 114 | US9603854, 114) Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc(C)c(F)c2)c2CCCCn12 Show InChI InChI=1S/C44H45FN4O5/c1-29-10-11-33(24-40(29)45)49(32-12-14-35(50)15-13-32)44(52)39-26-42(47-18-6-5-9-41(39)47)38-25-36(53-2)16-17-37(38)43(51)48-27-31-8-4-3-7-30(31)23-34(48)28-46-19-21-54-22-20-46/h3-4,7-8,10-17,24-26,34,50H,5-6,9,18-23,27-28H2,1-2H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177890 (US9120791, Example 119 | US9603854, 119) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cccc(c1)C#N Show InChI InChI=1S/C43H40ClN5O4/c44-32-11-16-37(42(51)48-27-31-8-2-1-7-30(31)23-35(48)28-46-18-20-53-21-19-46)38(24-32)41-25-39(40-10-3-4-17-47(40)41)43(52)49(33-12-14-36(50)15-13-33)34-9-5-6-29(22-34)26-45/h1-2,5-9,11-16,22,24-25,35,50H,3-4,10,17-21,23,27-28H2/t35-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177899 (US9120791, Example 129 | US9603854, 129) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(cc1)C#N Show InChI InChI=1S/C43H40ClN5O4/c44-32-10-17-37(42(51)48-27-31-6-2-1-5-30(31)23-35(48)28-46-19-21-53-22-20-46)38(24-32)41-25-39(40-7-3-4-18-47(40)41)43(52)49(34-13-15-36(50)16-14-34)33-11-8-29(26-45)9-12-33/h1-2,5-6,8-17,24-25,35,50H,3-4,7,18-23,27-28H2/t35-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139591 (4-(5-{[2-(3-Fluoro-phenyl)-3-oxo-2,3,4,5-tetrahydr...) Show SMILES Fc1cccc(c1)N1Cc2ccccc2CC(NCc2cncn2Cc2ccc(cc2)C#N)C1=O Show InChI InChI=1S/C28H24FN5O/c29-24-6-3-7-25(13-24)34-18-23-5-2-1-4-22(23)12-27(28(34)35)32-16-26-15-31-19-33(26)17-21-10-8-20(14-30)9-11-21/h1-11,13,15,19,27,32H,12,16-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177880 (US9120791, Example 108 | US9603854, 108) Show SMILES COCCN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)c2CCCCn12 Show InChI InChI=1S/C45H46ClN5O4/c1-47(22-23-55-3)29-36-24-30-8-4-5-9-32(30)28-50(36)44(53)38-17-11-33(46)26-39(38)43-27-40(42-10-6-7-20-49(42)43)45(54)51(34-12-15-37(52)16-13-34)35-14-18-41-31(25-35)19-21-48(41)2/h4-5,8-9,11-19,21,25-27,36,52H,6-7,10,20,22-24,28-29H2,1-3H3/t36-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177883 (US9120791, Example 112 | US9603854, 112) Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccccc2)c2ccc(O)cc2)c2CCCCn12 Show InChI InChI=1S/C43H44N4O5/c1-51-36-18-19-37(42(49)46-28-31-10-6-5-9-30(31)25-34(46)29-44-21-23-52-24-22-44)38(26-36)41-27-39(40-13-7-8-20-45(40)41)43(50)47(32-11-3-2-4-12-32)33-14-16-35(48)17-15-33/h2-6,9-12,14-19,26-27,34,48H,7-8,13,20-25,28-29H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177885 (US9120791, Example 114 | US9603854, 114) Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc(C)c(F)c2)c2CCCCn12 Show InChI InChI=1S/C44H45FN4O5/c1-29-10-11-33(24-40(29)45)49(32-12-14-35(50)15-13-32)44(52)39-26-42(47-18-6-5-9-41(39)47)38-25-36(53-2)16-17-37(38)43(51)48-27-31-8-4-3-7-30(31)23-34(48)28-46-19-21-54-22-20-46/h3-4,7-8,10-17,24-26,34,50H,5-6,9,18-23,27-28H2,1-2H3/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177890 (US9120791, Example 119 | US9603854, 119) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cccc(c1)C#N Show InChI InChI=1S/C43H40ClN5O4/c44-32-11-16-37(42(51)48-27-31-8-2-1-7-30(31)23-35(48)28-46-18-20-53-21-19-46)38(24-32)41-25-39(40-10-3-4-17-47(40)41)43(52)49(33-12-14-36(50)15-13-33)34-9-5-6-29(22-34)26-45/h1-2,5-9,11-16,22,24-25,35,50H,3-4,10,17-21,23,27-28H2/t35-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177899 (US9120791, Example 129 | US9603854, 129) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(cc1)C#N Show InChI InChI=1S/C43H40ClN5O4/c44-32-10-17-37(42(51)48-27-31-6-2-1-5-30(31)23-35(48)28-46-19-21-53-22-20-46)38(24-32)41-25-39(40-7-3-4-18-47(40)41)43(52)49(34-13-15-36(50)16-14-34)33-11-8-29(26-45)9-12-33/h1-2,5-6,8-17,24-25,35,50H,3-4,7,18-23,27-28H2/t35-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177878 (US9120791, Example 105 | US9603854, 105) Show SMILES COCCN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-c2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3CCCCn23)CC1 Show InChI InChI=1S/C46H49N5O6/c1-55-24-23-47-19-21-48(22-20-47)30-36-25-32-9-5-6-10-33(32)29-50(36)45(53)39-28-44-43(56-31-57-44)27-38(39)42-26-40(41-13-7-8-18-49(41)42)46(54)51(34-11-3-2-4-12-34)35-14-16-37(52)17-15-35/h2-6,9-12,14-17,26-28,36,52H,7-8,13,18-25,29-31H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177887 (US9120791, Example 116 | US9603854, 116) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cccc(F)c1 Show InChI InChI=1S/C42H40ClFN4O4/c43-30-11-16-36(41(50)47-26-29-7-2-1-6-28(29)22-34(47)27-45-18-20-52-21-19-45)37(23-30)40-25-38(39-10-3-4-17-46(39)40)42(51)48(32-12-14-35(49)15-13-32)33-9-5-8-31(44)24-33/h1-2,5-9,11-16,23-25,34,49H,3-4,10,17-22,26-27H2/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177898 (US9120791, Example 128 | US9603854, 128) Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-c2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3CCCCn23)CC1=O Show InChI InChI=1S/C44H43N5O6/c1-45-19-20-46(27-42(45)51)26-33-21-29-9-5-6-10-30(29)25-48(33)43(52)36-24-41-40(54-28-55-41)23-35(36)39-22-37(38-13-7-8-18-47(38)39)44(53)49(31-11-3-2-4-12-31)32-14-16-34(50)17-15-32/h2-6,9-12,14-17,22-24,33,50H,7-8,13,18-21,25-28H2,1H3/t33-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139585 (4-(5-{[2-(3,5-Difluoro-phenyl)-3-oxo-2,3,4,5-tetra...) Show SMILES Fc1cc(F)cc(c1)N1Cc2ccccc2CC(NCc2cncn2Cc2ccc(cc2)C#N)C1=O Show InChI InChI=1S/C28H23F2N5O/c29-23-10-24(30)12-25(11-23)35-17-22-4-2-1-3-21(22)9-27(28(35)36)33-15-26-14-32-18-34(26)16-20-7-5-19(13-31)6-8-20/h1-8,10-12,14,18,27,33H,9,15-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139592 (4-(5-{[2-(2-Chloro-benzyl)-3-oxo-2,3,4,5-tetrahydr...) Show SMILES Clc1ccccc1CN1Cc2ccccc2CC(NCc2cncn2Cc2ccc(cc2)C#N)C1=O Show InChI InChI=1S/C29H26ClN5O/c30-27-8-4-3-7-25(27)19-34-18-24-6-2-1-5-23(24)13-28(29(34)36)33-16-26-15-32-20-35(26)17-22-11-9-21(14-31)10-12-22/h1-12,15,20,28,33H,13,16-19H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177878 (US9120791, Example 105 | US9603854, 105) Show SMILES COCCN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-c2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3CCCCn23)CC1 Show InChI InChI=1S/C46H49N5O6/c1-55-24-23-47-19-21-48(22-20-47)30-36-25-32-9-5-6-10-33(32)29-50(36)45(53)39-28-44-43(56-31-57-44)27-38(39)42-26-40(41-13-7-8-18-49(41)42)46(54)51(34-11-3-2-4-12-34)35-14-16-37(52)17-15-35/h2-6,9-12,14-17,26-28,36,52H,7-8,13,18-25,29-31H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177887 (US9120791, Example 116 | US9603854, 116) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cccc(F)c1 Show InChI InChI=1S/C42H40ClFN4O4/c43-30-11-16-36(41(50)47-26-29-7-2-1-6-28(29)22-34(47)27-45-18-20-52-21-19-45)37(23-30)40-25-38(39-10-3-4-17-46(39)40)42(51)48(32-12-14-35(49)15-13-32)33-9-5-8-31(44)24-33/h1-2,5-9,11-16,23-25,34,49H,3-4,10,17-22,26-27H2/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177898 (US9120791, Example 128 | US9603854, 128) Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-c2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3CCCCn23)CC1=O Show InChI InChI=1S/C44H43N5O6/c1-45-19-20-46(27-42(45)51)26-33-21-29-9-5-6-10-30(29)25-48(33)43(52)36-24-41-40(54-28-55-41)23-35(36)39-22-37(38-13-7-8-18-47(38)39)44(53)49(31-11-3-2-4-12-31)32-14-16-34(50)17-15-32/h2-6,9-12,14-17,22-24,33,50H,7-8,13,18-21,25-28H2,1H3/t33-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177870 (US9120791, Example 96 | US9603854, 96) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H43N5O6/c1-46-16-14-30-22-33(10-13-39(30)46)50(32-8-11-35(51)12-9-32)45(53)38-23-41(48-15-4-7-40(38)48)36-24-42-43(56-28-55-42)25-37(36)44(52)49-26-31-6-3-2-5-29(31)21-34(49)27-47-17-19-54-20-18-47/h2-3,5-6,8-14,16,22-25,34,51H,4,7,15,17-21,26-28H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177870 (US9120791, Example 96 | US9603854, 96) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C45H43N5O6/c1-46-16-14-30-22-33(10-13-39(30)46)50(32-8-11-35(51)12-9-32)45(53)38-23-41(48-15-4-7-40(38)48)36-24-42-43(56-28-55-42)25-37(36)44(52)49-26-31-6-3-2-5-29(31)21-34(49)27-47-17-19-54-20-18-47/h2-3,5-6,8-14,16,22-25,34,51H,4,7,15,17-21,26-28H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177795 (US9120791, Example 13) Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-c2cc(C(=O)N(c3ccc(O)cc3)c3ccc4n(C)ccc4c3)c3CCCCn23)CC1 Show InChI InChI=1S/C47H48N6O5/c1-48-19-21-50(22-20-48)29-36-23-31-7-3-4-8-33(31)28-52(36)46(55)39-27-45-44(57-30-58-45)26-38(39)43-25-40(42-9-5-6-17-51(42)43)47(56)53(34-10-13-37(54)14-11-34)35-12-15-41-32(24-35)16-18-49(41)2/h3-4,7-8,10-16,18,24-27,36,54H,5-6,9,17,19-23,28-30H2,1-2H3/t36-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 306 total )  |  Next  |  Last  >>

Jump to: