| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C8 |
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| Ligand | BDBM50271507 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_552426 (CHEMBL1001843) |
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| IC50 | 2800±n/a nM |
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| Citation |  Raghavan, S; Tria, GS; Shen, HC; Ding, FX; Taggart, AK; Ren, N; Wilsie, LC; Krsmanovic, ML; Holt, TG; Wolff, MS; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists. Bioorg Med Chem Lett18:3163-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C8 |
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| Name: | Cytochrome P450 2C8 |
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| Synonyms: | CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 55839.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10632 |
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| Residue: | 490 |
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| Sequence: | MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
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| BDBM50271507 |
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| n/a |
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| Name | BDBM50271507 |
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| Synonyms: | 2-(3-(2-(2-chloro-4-hydroxyphenyl)thiazol-4-yl)propanamido)benzoic acid | CHEMBL482480 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15ClN2O4S |
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| Mol. Mass. | 402.851 |
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| SMILES | OC(=O)c1ccccc1NC(=O)CCc1csc(n1)-c1ccc(O)cc1Cl |
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| Structure | 
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