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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Peroxisome proliferator-activated receptor alpha | ||
| Ligand | BDBM50261878 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_513557 (CHEMBL979053) | ||
| EC50 | 0.6±n/a nM | ||
| Citation |  Pingali, H; Jain, M; Shah, S; Makadia, P; Zaware, P; Goel, A; Patel, M; Giri, S; Patel, H; Patel, P Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists. Bioorg Med Chem16:7117-27 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Peroxisome proliferator-activated receptor alpha | |||
| Name: | Peroxisome proliferator-activated receptor alpha | ||
| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 52222.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07869 | ||
| Residue: | 468 | ||
| Sequence: |
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| BDBM50261878 | |||
| n/a | |||
| Name | BDBM50261878 | ||
| Synonyms: | 2-Methyl-c-5-{4-[5-methyl-2-(5-methylthiophen-2-yl)oxazol-4-ylmethoxy]benzyl}-1,3-dioxane-s-2-carboxylic acid | CHEMBL468159 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H25NO6S | ||
| Mol. Mass. | 443.513 | ||
| SMILES | Cc1ccc(s1)-c1nc(COc2ccc(C[C@H]3CO[C@](C)(OC3)C(O)=O)cc2)c(C)o1 |r,wU:16.16,19.24,wD:19.20,(16.23,-2.7,;17.45,-1.75,;17.4,-.22,;18.85,.31,;19.79,-.9,;18.92,-2.18,;21.33,-.86,;22.2,.42,;23.68,-.01,;25.03,.73,;26.34,-.07,;27.7,.67,;29.01,-.14,;30.36,.59,;30.4,2.13,;31.75,2.87,;33.06,2.07,;34.41,2.82,;35.72,2.01,;35.68,.47,;37.16,.87,;34.33,-.26,;33.02,.54,;36.12,-1,;37.62,-1.36,;35.06,-2.12,;29.07,2.94,;27.73,2.2,;23.72,-1.55,;25,-2.42,;22.28,-2.07,)| | ||
| Structure | 
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