| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
|---|
| Ligand | BDBM50265183 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_496716 (CHEMBL1005353) |
|---|
| IC50 | 2400±n/a nM |
|---|
| Citation |  Lansdell, MI; Burring, DJ; Hepworth, D; Strawbridge, M; Graham, E; Guyot, T; Betson, MS; Hart, JD Design and synthesis of fluorescent SGLT2 inhibitors. Bioorg Med Chem Lett18:4944-7 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/glucose cotransporter 2 |
|---|
| Name: | Sodium/glucose cotransporter 2 |
|---|
| Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 72902.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31639 |
|---|
| Residue: | 672 |
|---|
| Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
|
|
|
|---|
| BDBM50265183 |
|---|
| n/a |
|---|
| Name | BDBM50265183 |
|---|
| Synonyms: | (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((7-nitrobenzo[c][1,2,5]oxadiazol-4-ylamino)methyl)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | CHEMBL500899 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25ClN4O8 |
|---|
| Mol. Mass. | 556.952 |
|---|
| SMILES | OCC1OC(C(O)C(O)C1O)c1ccc(Cl)c(Cc2ccc(CNc3ccc([N+]([O-])=O)c4[n-][o+]nc34)cc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
