Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50281983

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_40194

IC50

99±n/a nM

Citation

Eden, JM; Horwell, DC; Pritchard, MC α-β-didehydrotryptophan as a surrogate for α-methyltryptophan in CCK ‘peptoids’ related to CI-988. Bioorg Med Chem Lett3:989-992 (1993) Article

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49196.59

Organism:

MOUSE

Description:

Cholecystokinin A CCKBR MOUSE::P56481

Residue:

453

Sequence:

MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGL
ISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCY
VQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANT
WRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50281983

n/a

Name

BDBM50281983

Synonyms:

(R)-3-[(Z)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-acryloylamino]-4-phenyl-butyric acid | 3-[2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-acryloylamino]-4-phenyl-butyric acid | CHEMBL177081

Type

Small organic molecule

Emp. Form.

C32H35N3O5

Mol. Mass.

541.6374

SMILES

OC(=O)C[C@@H](Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)=NC(=O)OC1C2CC3CC(C2)CC1C3 |w:26.29,wU:4.12,TLB:36:31:39:35.37.34,36:35:30.31.32:39,THB:34:35:30:33.32.39,34:33:30:35.37.36,29:30:39:35.37.34,(11.52,-.26,;12.15,-1.68,;13.66,-1.87,;11.19,-2.89,;11.77,-4.31,;13.29,-4.54,;14.68,-3.89,;14.82,-2.36,;16.22,-1.73,;17.5,-2.61,;17.35,-4.15,;15.94,-4.8,;10.81,-5.52,;9.29,-5.29,;8.73,-3.87,;8.35,-6.5,;6.82,-6.29,;5.87,-7.47,;6.29,-8.96,;5.01,-9.82,;3.79,-8.87,;2.26,-9.12,;1.29,-7.91,;1.85,-6.5,;3.36,-6.24,;4.33,-7.43,;8.91,-7.94,;10.35,-8.47,;10.6,-9.98,;11.75,-7.82,;13,-8.71,;12.98,-10.43,;14.47,-11.01,;15.74,-10.33,;15.09,-11.64,;13.52,-11.1,;12.33,-11.64,;13.54,-9.17,;14.45,-7.98,;15.75,-8.78,)|

Structure