Ki Summary

Reaction Details

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Target

Substance-P receptor

Ligand

BDBM50284274

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_205720 (CHEMBL807966)

IC50

32.7±n/a nM

Citation

Lowe, JA; Drozda, SE; McLean, S; Crawford, RT; Bryce, DK; Bordner, J N-alkyl quinuclidinium substance P antagonists Bioorg Med Chem Lett4:1153-1156 (1994) Article

More Info.:

Get all data from this article, Assay Method

Substance-P receptor

Name:

Substance-P receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46254.43

Organism:

Homo sapiens (Human)

Description:

P25103

Residue:

407

Sequence:

MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS

BDBM50284274

n/a

Name

BDBM50284274

Synonyms:

(2S,3S)-2-Benzhydryl-1-ethoxycarbonylmethyl-3-(2-methoxy-benzylamino)-1-azonia-bicyclo[2.2.2]octane; bromide | CHEMBL278455

Type

Small organic molecule

Emp. Form.

C32H39N2O3

Mol. Mass.

499.6631

SMILES

CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 |wD:12.13,23.26,(-.96,-9.33,;.12,-10.42,;1.62,-10.01,;2.01,-8.53,;.92,-7.43,;3.5,-8.12,;3.88,-6.64,;2.57,-5.87,;2.57,-4.33,;3.92,-3.55,;3.16,-4.89,;4.65,-5.3,;5.21,-4.33,;6.56,-3.55,;6.57,-2.01,;7.9,-1.26,;7.9,.27,;9.23,1.04,;10.57,.27,;10.56,-1.27,;9.23,-2.04,;10.31,-3.13,;11.79,-2.71,;5.21,-5.87,;6.56,-6.64,;6.54,-8.18,;5.21,-8.95,;5.21,-10.49,;6.54,-11.26,;7.89,-10.49,;7.87,-8.95,;7.89,-5.87,;7.89,-4.34,;9.22,-3.55,;10.56,-4.34,;10.56,-5.88,;9.22,-6.64,)|

Structure