| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50040468 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_28490 |
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| IC50 | 5300±n/a nM |
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| Citation |  Roth, BD; Roark, WH; Picard, JA; Stanfield, RL; Bousley, RF; Anderson, MK; Hamelehle, KL; Homan, R; Krause, BR Inhibitors of acyl-coa:cholesterol acyltransferase (ACAT). 15. sulfonylurea inhibitors with excellent hypocholesterolemic activity in vivo. Bioorg Med Chem Lett5:2367-2370 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64165.56 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_28796 |
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| Residue: | 545 |
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| Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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| BDBM50040468 |
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| n/a |
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| Name | BDBM50040468 |
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| Synonyms: | 2,6-Bis(1-methylethyl)phenyl[[2,6-Bis(1-methylethyl)phenoxy]sulfonyl]carbamate,Monosodium salt | Acylphosphoramidate analogue | CHEMBL25110 | Sodium salt of 2,6-bis(1-methylethyl)phenyl[[2,6-bis(1-methyl)phenoxy]-sulfonyl]carbamate | Sodium salt of CarboSulfamic acid Bis-(2,6-diisopropyl-phenyl ester) | sodium salt of 2,6-isopropylphenylcraboxy-sulfamic acid 2,6-diisopropyl-phenyl ester | sodium salt of Acyl Sulfamate derivatives |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34NO5S |
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| Mol. Mass. | 460.607 |
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| SMILES | CC(C)c1cccc(C(C)C)c1OC(=O)[N-]S(=O)(=O)Oc1c(cccc1C(C)C)C(C)C |
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| Structure | 
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