Reaction Details |
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Target | Type-1 angiotensin II receptor A/B |
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Ligand | BDBM50450370 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_36648 (CHEMBL652358) |
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IC50 | 3.7±n/a nM |
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Citation | Mederski, WW; Dorsch, D; Osswald, M; Beier, N; Lues, I; Minck, KO; Schelling, P; Ladstetter, BJ 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor Bioorg Med Chem Lett5:2665-2670 (1995) Article |
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More Info.: | Get all data from this article, Assay Method |
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Type-1 angiotensin II receptor A/B |
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Name: | Type-1 angiotensin II receptor A/B |
Synonyms: | Angiotensin II receptor (AT-1) type-1 | Type-1A/Type-1B angiotensin II receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 901964 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Type-1 angiotensin II receptor B |
Synonyms: | AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40929.44 |
Organism: | RAT |
Description: | Angiotensin II AT1B 0 RAT::P29089 |
Residue: | 359 |
Sequence: | MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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Component 2 |
Name: | Type-1 angiotensin II receptor A |
Synonyms: | AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40910.53 |
Organism: | RAT |
Description: | ANGIOTENSIN AT1 AGTR1 RAT::P25095 |
Residue: | 359 |
Sequence: | MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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BDBM50450370 |
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n/a |
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Name | BDBM50450370 |
Synonyms: | CHEMBL313691 |
Type | Small organic molecule |
Emp. Form. | C43H61NO15 |
Mol. Mass. | 831.9421 |
SMILES | [H][C@@]12C[C@H](O)[C@@]3(C)[C@@H](O)[C@H](OC(C)=O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C |c:14| |
Structure |
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