| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50290959 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63345 |
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| IC50 | >100000±n/a nM |
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| Citation |  Dorsch, D; Mederski, WW; Osswald, M; Devant, RM; Schmitges, CJ; Christadler, M; Wilm, C Pyridazinones with a pendant acylsulfonamide moiety as endothelin receptor antagonists Bioorg Med Chem Lett7:275-280 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48256.91 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
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| Residue: | 426 |
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| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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| BDBM50290959 |
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| n/a |
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| Name | BDBM50290959 |
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| Synonyms: | CHEMBL96931 | N-{2-Benzo[1,3]dioxol-5-yl-2-[3-(2,5-dimethoxy-phenyl)-6-oxo-5,6-dihydro-4H-pyridazin-1-yl]-acetyl}-4-isopropyl-benzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31N3O8S |
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| Mol. Mass. | 593.647 |
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| SMILES | COc1ccc(OC)c(c1)C1=NN(C(C(=O)NS(=O)(=O)c2ccc(cc2)C(C)C)c2ccc3OCOc3c2)C(=O)CC1 |t:11| |
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| Structure | 
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